Half-Life Cancer Research Results

Half-Life, Half-Life: Click to Expand ⟱
Source:
Type:
For many drugs, the half-life is the time it takes for half of the drug’s active substance to be eliminated from the bloodstream.
In medicine, knowing a drug’s half-life helps in designing treatment regimens that reduce adverse effects.
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *eff↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, eff↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE↓, *cardioP↑, MFN2↑,
6469- 1,8-Cin,    Pharmacokinetic Studies of the Fragrance Compound 1,8-Cineol in Humans during Inhalation
- Human, Nor, NA
*BioAv↑, *Half-Life↝,
5291- 5-HTP,    Kinetics of l-5-hydroxytryptophan in healthy subjects
- in-vivo, Nor, NA
*Half-Life↝, *BioAv↑,
5456- AF,    Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent
- Trial, Nor, NA
*Dose?, *Half-Life↝, *Dose↑, *toxicity↝, *Bacteria↓, *Dose↑,
5455- AF,    Ridaura
- Study, PSA, NA
Dose↝, Half-Life↝,
5443- AG,    Pharmacokinetics and tolerance of toal astragalosides after intravenous infusion of astragalosides injection in healthy Chinese volunteers
- Human, Nor, NA
*Dose↝, Half-Life↝, *toxicity↓,
4600- AgNPs,    Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model
- in-vivo, Nor, NA
*Half-Life↝, *toxicity↓, *Dose↑, *other↝, *eff↝, *BioAv↓,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
5355- AL,    Mini-review: The health benefits and applications of allicin
- Review, Var, NA
*BioAv↑, *cardioP↑, *hepatoP↑, *RenoP↑, *Half-Life↝, *BioAv↓, *neuroP↑, *cognitive↑, *ROS↓, *lipid-P↓, *DNArepair↑, *ChemoSen↑,
5322- ALC,    Comparison of pharmacokinetics of L-carnitine, Acetyl-L-carnitine and Propionyl-Lcarnitine after single oral administration of L-carnitine in healthy volunteers
- Human, Nor, NA
*Half-Life↝,
2569- ART/DHA,    A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first-pass hepatic extraction
- Human, Nor, NA
*Half-Life↝, BioAv↝, *Half-Life↓, BioAv↑, *Dose↝,
3155- Ash,    Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera
- Review, Var, NA
Half-Life↝, Inflam↓, antiOx↓, angioG↓, ROS↑, BAX↑, Bak↑, E6↓, E7↓, P53↑, Casp3↑, cl‑PARP↑, STAT3↓, eff↑, HSP90↓, TGF-β↓, TNF-α↓, EMT↑, mTOR↓, NOTCH1↓, p‑Akt↓, NF-kB↓, Dose↝,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
5423- ASTX,    Pharmacokinetic Profile of Astaxanthin Nanoemulsion Using HPLC (High-Performance Liquid Chromatography) With Oral Routes
- in-vivo, Nor, NA
*BioAv↓, *antiOx↑, *BioAv↑, *Half-Life↝,
5373- ATO,    arsenic trioxide
- Human, APL, NA
Half-Life↝,
5445- ATV,    Atorvastatin
- NA, Nor, NA
*cardioP↑, *LDL↓, HMG-CoA↓, Half-Life↝, BioAv↓, Dose↝,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
5500- Ba,    Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single‐center, randomized, double‐blind, placebo‐controlled multiple‐ascending‐dose study
- Trial, Nor, NA
*toxicity↓, *BioAv↑, *Half-Life↝, *Dose↝,
2671- BBR,    Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action
- in-vivo, Diabetic, NA
*BioAv↓, *Half-Life↝, *OCR↓, *AMPK↑,
3680- BBR,    Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
- in-vivo, AD, NA
*Akt↑, *neuroP↑, *p‑ERK↑, *Aβ↓, *Inflam↓, *ROS↓, *BioAv↑, *BBB↑, *Half-Life↝, *memory↑, *cognitive↑, *HSP90↑, *APP↓, *mTOR↓, *P70S6K↓, *CD31↑, *VEGF↑, *N-cadherin↑, *Apoptosis↓,
2716- BetA,    Cellular and molecular mechanisms underlying the potential of betulinic acid in cancer prevention and treatment
- Review, Var, NA
AntiCan↑, TumCD↑, TumCCA↑, ROS↑, NF-kB↓, Bcl-2↓, Half-Life↝, GLUT1↓, VEGF↓, PDK1↓,
5676- BML,    Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake
- in-vivo, NA, NA
Half-Life↝, Dose↝, Dose↝,
5654- BNL,    Pharmacokinetics of natural borneol after oral administration in mice brain and its effect on excitation ratio
- in-vivo, Nor, NA
*BioAv↑, *Half-Life↝, other↝,
5669- BNL,    Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol
- Review, Nor, NA - Review, AD, NA - Review, Stroke, NA
*eff↑, *eff↑, *toxicity↝, *Inflam↓, *Bacteria↓, *neuroP↑, *Half-Life↝, *BBB↑, *BioEnh↑, *P-gp↓, *CYP3A4↓, *ROS↓, *neuroP↑,
5672- Bor,    A comparative review of the pharmacokinetics of boric acid in rodents and humans
- in-vivo, Nor, NA
*Half-Life↝,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
3512- Bor,    Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake
- in-vitro, Pca, DU145
TumCP↓, eIF2α↑, ATF4↑, ATF6↑, GADD34↑, CHOP↓, GRP78/BiP↑, GRP94↑, Risk↓, *BMD↑, Ca+2↓, *Half-Life↝, IRE1∅, chemoP↑,
4624- Bor,  VitD3,    Boron as a Medicinal Ingredient in Oral Natural Health Products
- Review, Pca, NA
*Half-Life↝, *eff↑, PSA↓, TumVol↓, IGF-1↓, *memory↓, *motorD↓,
5825- CAP,    Bioavailability of capsaicin and its implications for drug delivery
- Review, Var, NA - Review, Arthritis, NA - Review, Obesity, NA
*AntiCan↑, *TRPV1↑, *cardioP↑, AntiCan↓, Apoptosis↑, ChemoSen↑, *Inflam↓, *Pain↓, *AntiAg↑, *Weight↓, *BioAv↑, BioAv↑, Half-Life↝, Half-Life↓,
5879- CAR,    Pharmacokinetic analysis of thymol, carvacrol and diallyl disulfide after intramammary and topical applications in healthy organic dairy cattle
- in-vivo, Nor, NA
*Dose↝, Half-Life↝, Half-Life↝, Half-Life↝,
5811- CBC,    The Potential of Cannabichromene (CBC) as a Therapeutic Agent
- Review, Var, NA
*eff?, *Half-Life↝, *Inflam↓,
6636- Cen,    Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized Centella asiatica Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial
- Trial, AD, NA
*cognitive↑, *NRF2↑, *Dose↝, *memory↑, *ROS↓, *mitResp↑, *neuroP↑, *Half-Life↝, *Half-Life↝, *Half-Life↝,
6024- CGA,    Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up
- Trial, GBM, NA
*toxicity↓, Half-Life↝, BBB↑,
6029- CGA,    Pharmacokinetics of chlorogenic acids absorbed in human plasma and their metabolites following oral ingestion of coffee drink
- Trial, Nor, NA
*Dose↝, *BioAv↑, *Half-Life↝,
6194- Cuc,    Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats
- in-vivo, Nor, NA
*BioAv↓, *Half-Life↝, *AST∅, *ALAT∅, *RenoP↝, *Half-Life↝,
6195- Cuc,    Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
- Review, Var, NA
TumCG↓, Apoptosis↑, TumCCA↑, TumMeta↓, angioG↓, chemoPv↑, BioAv↓, Half-Life↝, cycD1/CCND1↓, cycE/CCNE↓, Casp3↑, cl‑PARP↑, JNK↑, Akt↓, ERK↓, survivin↓, XIAP↓, Bcl-2↓, Mcl-1↓, ROS↑, NRF2↓, FAK↓, MMP9↓, VEGF↓, VEGFR2↓, *NF-kB↓, TLR4↝, NLRP3↑, Pyro↑, GSH↓,
6185- Cuc,    Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics
- Review, Var, NA - Review, Arthritis, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *AntiCan↑, *toxicity↝, *BioAv↓, *HO-1↑, *NRF2↑, *NLRP3↑, *SOD↑, *SOD1↑, *ROS↓, *AntiAge↑, *ARE↑, *STAT↓, *NF-kB↓, *neuroG↑, *memory↑, ROS↑, NLRP3↑, CIP2A↓, Akt↓, STAT3↑, VEGFR2↓, DNMTs↓, MAPK↓, YAP/TEAD↓, PI3K↓, Wnt↓, NOTCH↓, TumCCA↑, TumCG↓, TumCP↓, FAK↑, MMP9↓, TumAuto↑, toxicity↝, BioAv↓, Half-Life↝, BioAv↑, selectivity∅,
2809- CUR,    Comparative absorption of curcumin formulations
- in-vivo, Nor, NA
BioAv↑, BioAv↑, BioAv↑, BioAv↑, BioAv↑, BioAv↓, Half-Life↝,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *eff↑,
6591- DAS,    Dasatinib in solid tumors
- Review, Var, NA
Src↓, PDGF↓, ABL1↓, BioAv↝, Half-Life↝, Dose↝, eff↑,
6679- DCA,    GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial
- Trial, Melanoma, NA
PDK1↓, Half-Life↝, eff↑, NP/CIPN↑, Dose↝, Half-Life↝,
6694- DFC,    Repurposing Drugs in Oncology (ReDO)—diclofenac as an anti-cancer agent
- Review, Var, NA
COX2↓, PGE2↓, angioG↓, ChemoSen↑, RadioS↑, Dose↝, toxicity↝, toxicity↝, BioAv↑, Half-Life↝, lactateProd↓, eff↑, *AntiAg↑,
6363- DRE,    Therapeutic Potential of Dandelion (Taraxacum officinale) Root Extract in Colon Cancer: A Comprehensive Review
- in-vitro, CRC, NA
Apoptosis↑, *Inflam↓, TLR4↓, NF-kB↓, *GutMicro↑, mtDam↑, *ROS↓, Casp1↑, TNF-α↑, Bcl-2↓, PARP↓, MMP↓, Cyt‑c↓, Casp3↑, TumVol↓, COX2↓, iNOS↓, ROS↑, selectivity↑, TumCMig↓, TumCI↓, ER Stress↑, PERK↑, eIF2α↑, ATF4↑, CHOP↑, TumCCA↑, cycD1/CCND1↓, P21↓, P53↑, BioAv↝, Half-Life↝,
6604- Ech,    Echinacea alkamide disposition and pharmacokinetics in humans after tablet ingestion
- Human, Nor, NA
*BioAv↑, *Half-Life↝, *Dose↝, Dose?,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
2561- EGCG,  ASA,    Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment
- ex-vivo, Nor, NA
AntiAg↑, eff↑, Half-Life↝, other∅,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
2824- FIS,    Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics
- Review, Var, NA
*antiOx↑, *Inflam↓, angioG↓, BioAv↓, BioAv↑, TumCP↓, TumCI↓, TumCMig↓, *neuroP↑, EMT↓, ROS↑, selectivity↑, EGFR↓, NF-kB↓, VEGF↓, MMP9↓, MMP↓, cl‑PARP↑, Casp7↑, Casp8↑, Casp9↑, *ROS↓, uPA↓, MMP1↓, Wnt↓, Akt↓, PI3K↓, ERK↓, Half-Life↝,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
6572- Ger,    Pharmacokinetics of Geraniol and Its Metabolites in Mice After Oral Administration
- in-vivo, Nor, NA
BioAv↝, BBB↑, BioAv↝, Half-Life↝,

Showing Research Papers: 1 to 50 of 90
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 90

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   GSH↓, 2,   HO-1↑, 1,   MFN2↑, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 1,   OXPHOS↓, 1,   ROS↓, 2,   ROS↑, 10,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ABL1↓, 1,   MMP↓, 3,   mtDam↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   AMPK↑, 2,   FASN↓, 1,   GlutMet↓, 1,   HMG-CoA↓, 1,   lactateProd↓, 1,   LDH↓, 1,   PDK1↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 6,   p‑Akt↓, 1,   Apoptosis↑, 5,   Bak↑, 2,   BAX↑, 3,   Bcl-2↓, 6,   Bcl-xL↓, 1,   Casp↑, 1,   Casp1↑, 1,   Casp12↑, 1,   Casp3↑, 7,   cl‑Casp3⇅, 1,   Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 4,   Diablo↑, 1,   Fas↑, 1,   GADD34↑, 1,   HGF/c-Met↓, 1,   iNOS↓, 1,   JNK↑, 3,   MAPK↓, 2,   MAPK↝, 1,   Mcl-1↓, 1,   p27↑, 1,   p38↑, 2,   Pyro↑, 1,   survivin↓, 2,   Telomerase↓, 1,   TumCD↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p70S6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   other↝, 1,   other∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP↓, 1,   CHOP↑, 1,   eIF2α↑, 2,   ER Stress↑, 2,   GRP78/BiP↑, 2,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 2,   IRE1↑, 1,   IRE1∅, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CHK1↓, 1,   DNAdam↑, 1,   DNMTs↓, 2,   P53↑, 6,   PARP↓, 1,   PARP↑, 1,   cl‑PARP↑, 5,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 2,   P21↓, 1,   P21↑, 2,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,   CIP2A↓, 1,   CSCs↓, 1,   EMT↓, 3,   EMT↑, 1,   ERK↓, 2,   FOXO3↑, 1,   HDAC↓, 1,   IGF-1↓, 1,   mTOR↓, 3,   mTOR↝, 1,   mTORC1↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   NOTCH3↓, 1,   PI3K↓, 4,   PTEN↑, 1,   Src↓, 1,   STAT3↓, 3,   STAT3↑, 1,   TumCG↓, 2,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↓, 1,   Ca+2↑, 1,   E-cadherin↑, 1,   FAK↓, 1,   FAK↑, 1,   p‑FAK↓, 1,   MMP1↓, 1,   MMP2↓, 1,   MMP9↓, 5,   MMPs↓, 1,   N-cadherin↓, 2,   PDGF↓, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumCP↓, 4,   TumMeta↓, 1,   uPA↓, 3,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   ATF4↑, 3,   EGFR↓, 1,   Hif1a↓, 2,   NO↑, 1,   VEGF↓, 4,   VEGFR2↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 4,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 1,   NF-kB↓, 6,   PGE2↓, 2,   PSA↓, 1,   TLR4↓, 1,   TLR4↝, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 10,   BioAv↝, 5,   ChemoSen↑, 4,   Dose?, 1,   Dose↝, 9,   eff↑, 11,   Half-Life↓, 1,   Half-Life↝, 24,   RadioS↑, 3,   selectivity↑, 2,   selectivity∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

E6↓, 1,   E7↓, 1,   EGFR↓, 1,   IL6↓, 1,   LDH↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 2,   chemoP↑, 3,   chemoPv↑, 1,   neuroP↑, 1,   NP/CIPN↑, 1,   Risk↓, 1,   toxicity↝, 3,   TumVol↓, 2,  
Total Targets: 182

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   TRPA1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 10,   ARE↑, 2,   Bil↑, 1,   Catalase↑, 3,   Fenton↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 2,   GSH↑, 4,   GSTs↑, 1,   HO-1↑, 5,   Keap1↓, 1,   lipid-P↓, 7,   MDA↓, 5,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 8,   RNS↓, 1,   ROS↓, 15,   SOD↑, 7,   SOD1↑, 2,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 1,   TOS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↑, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ALAT↓, 1,   ALAT∅, 1,   AMPK↑, 3,   p‑cMyc↑, 1,   CYP3A4↓, 1,   H2S↑, 1,   LDH↓, 2,   LDL↓, 1,   NADPH↑, 1,   PPARγ↓, 1,   PPARγ↑, 1,   p‑PPARγ↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   Apoptosis↓, 1,   iNOS↓, 4,   JNK↓, 1,   p‑MAPK↓, 1,   p38↓, 1,   TRPV1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,   HSP90↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   p‑ERK↑, 1,   GSK‐3β↓, 2,   IGF-1R↓, 1,   mTOR↓, 1,   neuroG↑, 1,   P70S6K↓, 1,   PI3K↓, 1,   STAT↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 2,   APP↓, 1,   Ca+2↓, 1,   CD31↑, 1,   COL1↑, 1,   MMP2↓, 1,   N-cadherin↑, 1,   TGF-β↑, 1,   VCAM-1↓, 1,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   NO↓, 2,   PDGFR-BB↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 6,   P-gp↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 5,   ICAM-1↓, 1,   IL18↓, 1,   IL1β↓, 5,   IL6↓, 6,   IL8↓, 3,   Inflam↓, 15,   JAK↓, 1,   JAK2↓, 1,   NF-kB↓, 8,   PGE2↓, 3,   TLR4↓, 1,   TNF-α↓, 7,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   ChAT↑, 1,   tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 4,   BACE↓, 1,   NLRP3↓, 2,   NLRP3↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9,   BioAv↑, 14,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↑, 1,   Dose?, 1,   Dose↑, 4,   Dose↝, 10,   eff?, 1,   eff↑, 6,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 33,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALAT∅, 1,   AST↓, 1,   AST∅, 1,   Bil↑, 1,   BMD↑, 2,   BP↓, 1,   creat↓, 1,   GutMicro↑, 3,   IL6↓, 6,   LDH↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 3,   cardioP↑, 7,   chemoPv↑, 1,   cognitive↑, 6,   hepatoP↓, 1,   hepatoP↑, 5,   memory↓, 1,   memory↑, 6,   motorD↓, 1,   neuroP↑, 13,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 2,   RenoP↝, 1,   toxicity↓, 6,   toxicity↝, 3,   toxicity∅, 1,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,  
Total Targets: 154

Scientific Paper Hit Count for: Half-Life, Half-Life
4 Boron
4 Resveratrol
3 Cucurbitacin
3 Silymarin (Milk Thistle) silibinin
3 Shikonin
3 Selenite (Sodium)
2 1,8-Cineole
2 Auranofin
2 Allicin (mainly Garlic)
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Berberine
2 borneol
2 Chlorogenic acid
2 Curcumin
2 EGCG (Epigallocatechin Gallate)
2 Fisetin
2 Honokiol
2 Luteolin
2 Metformin
2 Rosmarinic acid
2 Thymoquinone
2 Urolithin
1 5-Hydroxytryptophan
1 Astragalus
1 Silver-NanoParticles
1 Acetyl-l-carnitine
1 Artemisinin
1 Astaxanthin
1 Arsenic trioxide
1 Atorvastatin
1 Betulinic acid
1 Bromelain
1 Vitamin D3
1 Capsaicin
1 Carvacrol
1 Cannabichromene
1 Centella asiatica / Gotu kola → asiaticoside
1 Dasatinib/Phyrago
1 Dichloroacetate
1 Diclofenac
1 Dandelion Root
1 Echinacea
1 Aspirin
1 Ferulic acid
1 Geraniol
1 itraconazole
1 Methylene blue
1 Methyl salicylate / Sweet Birch oil
1 Methylsulfonylmethane
1 Oleuropein
1 HydroxyTyrosol
1 Propolis -bee glue
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Phosphatidylserine
1 Pterostilbene
1 SonoDynamic Therapy UltraSound
1 Sulforaphane (mainly Broccoli)
1 Radiotherapy/Radiation
1 Thyme
1 Thymol-Thymus vulgaris
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1109  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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