BBB Cancer Research Results

BBB, Blood-Brain Barrier Permeability: Click to Expand ⟱
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Type:
Blood-Brain Barrier(BBB) is a term often used regarding if a product has the ability to cross the BBB.
Scientific Papers found: Click to Expand⟱
4583- AgNPs,    Metal-Based Nanoparticles for Cardiovascular Diseases
- Review, NA, NA
RadioS↑, enhancing radiation-based anticancer therapy
*ROS↑, Silver nanoparticles (AgNPs) produce a pro-oxidant environment, though it is still unclear exactly how they increase reactive oxygen species (ROS).
*BBB↝, research contends that these particles mainly spare the blood–brain barrier (BBB) from toxicity, other reports found that administering AgNP altered the BBB’s permeability, providing a fascinating potential avenue for future applications

5317- ALC,    Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2
- in-vivo, Nor, NA
*BBB↝, These results indicated that OCTN2 is functionally involved in ALCAR transfer across the BBB. T

5473- BM,    Bacopa monnieri: Preclinical and Clinical Evidence of Neuroactive Effects, Safety of Use and the Search for Improved Bioavailability
- in-vivo, AD, NA - in-vivo, Park, NA
*neuroP↑, results in reducing symptoms and protecting against neurodegeneration.
*toxicity∅, Bacopa monnieri has been found to be generally non-toxic, with no serious side effects reported.
*AChE↓, The neuroprotective effect of Bacopa monnieri was likely due to its ability to inhibit acetylcholinesterase activity rather than mitigating glutamate-induced toxicity.
*ROS↓, neurons treated with the extract exhibited lower levels of reactive oxygen species, suggesting a reduction in intracellular oxidative stress and an extension of neuronal lifespan.
*antiOx↑, The extract also demonstrated antioxidant properties and inhibited lipid peroxidation
*lipid-P↓,
*cognitive↑, on 72 mice, it was shown that supplementation with Bacopa monnieri (100 mg/kg for 180 days) significantly improved cognitive function.
*memory↑, 60 healthy, elderly volunteers taking 300 mg and 600 mg of Brahmi showed reduced acetylcholinesterase activity, which resulted in improved attention and memory.
*Dose↝, Ethanol extract was most commonly used in the studies. Doses are usually in the range of 300 to 600 mg daily.
*BioAv↓, Bacoside A is one of the main active compounds found in Bacopa monnieri. However, its water insolubility results in low bioavailability when administered orally.
*TumCCA↑, It has been shown to induce cell cycle arrest and apoptosis in colorectal cancer cell lines
*BBB↝, Studies were also conducted in which, similarly to the aforementioned approach, formulated solid lipid nanoparticles (SLNs) were used to facilitate the transport of the bacoside-rich extract across the blood–brain barrier.

6112- Chol,    Trimethylamine N-oxide induced cognitive impairment through disruption of blood-brain barrier by inhibiting TGF-β pathway
- in-vivo, AD, NA
*TMAO↑, (HFD) promotes cardiovascular disease, in part because it is rich in quaternary amines such as choline, carnitine, and lecithin, which are converted to trimethylamine (TMA) by the gut microbes and increase levels of circulating TMAO
*cognitive↓, TMAO induces cognitive impairment via disrupting the BBB. TMAO treatment induced cognitive impairment and disrupted the BBB integrity in mice
*BBB↝, TMAO has been reported to regulate blood-brain barrier (BBB) integrity and suppress the expression of tight junction proteins (TJs) in the microvasculature.
*TJ↝,

116- Myrrh,    The Role of Myrrh Metabolites in Cancer, Inflammation, and Wound Healing: Prospects for a Multi-Targeted Drug Therapy
- in-vitro, AML, HL-60 - in-vitro, AML, K562 - in-vitro, BC, KAIMRC1
ROS↑, Myrrh caused a dose-dependent effect on macrophages to increase the reactive oxygen species (ROS) level
M1↑, promote their polarization to classically activated macrophages (M1) and alternatively activated macrophages (M2) phenotypes, and consequently induce apoptosis
M2 MC↑,
Apoptosis?,
BBB↝, myrrh resin extract, only compounds 3, 4, 5, and 8 are potentially not permeable to the blood-brain barrier (BBB)

3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, Neuroprotection by quercetin has been reported in several in vitro studies
*lipid-P↓, It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation.
*antiOx↑, In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways.
*Aβ↓,
*Inflam↓,
*BBB↝, It also has low BBB penetrability, thus limiting its efficacy in combating neurodegenerative disorders.
*NF-kB↓, downregulating pro-inflammatory cytokines, such as NF-kB and iNOS, while stimulating neuronal regeneration
*iNOS↓,
*memory↑, Quercetin has shown therapeutic efficacy, improving learning, memory, and cognitive functions in AD
*cognitive↑,
*AChE↓, Quercetin administration resulted in the inhibition of AChE
*MMP↑, quercetin ameliorates mitochondrial dysfunction by restoring mitochondrial membrane potential, decreases ROS production, and restores ATP synthesis
*ROS↓,
*ATP↑,
*AMPK↑, It also increased the expression of AMP-activated protein kinase (AMPK), which is a key cell regulator of energy metabolism.
*NADPH↓, Activated AMPK can decrease ROS generation by inhibiting NADPH oxidase activity
*p‑tau↓, Inhibition of AβAggregation and Tau Phosphorylation

3619- RosA,    Rosmarinic acid suppresses Alzheimer’s disease development by reducing amyloid β aggregation by increasing monoamine secretion
- Review, AD, NA
*BioAv↓, confirmed that the intestinal permeability of RA is <1% of its intake volume
*BBB↝, migrates to the brain with difficulty due to the presence of the BBB
*monoA↑, RA administration increases monoamines in the brain
*TGF-β↓, Several studies have reported that RA suppresses the expression of Tgf-β1 in vivo and in vitro2
*Aβ↓, Suppression of Aβ aggregation by DA and other monoamines

4329- VitB5,    Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer's Disease Pathogenesis in a Transgenic Mouse Model
- in-vivo, AD, NA
*Aβ↓, We have previously shown that pantethine treatment reduces amyloid-β (Aβ)-induced IL-1β release and alleviates pathological metabolic changes in primary astrocyte cultures
*Mood↑, We observed that long-term pantethine treatment significantly reduced glial reactivity and Αβ deposition, and abrogated behavioral alteration in Tg mice.
*neuroP↑, Pantethine elicits broad physiological activities involving multiple cellular pathways. It has been shown to exert neuroprotective effects
*Inflam↓, but also to decrease inflammation and mediate immune responses
*TNF-α↓, We have previously shown that pantethine is able to protect mice against cerebral malaria by preserving blood–brain barrier integrity and by lowering TNF-α levels
*BBB↝, Cysteamine can cross the blood–brain barrier [110] and was shown to induce the release of BDNF (brain-derived neurotrophic factor)
*other↝, The present study demonstrated the efficiency of pantethine to reverse AD features such as astrogliosis, microgliosis, Aβ deposition, and to AD-associated aggressive behavior.
*Dose↝, Based on our results, pantethine, provided routinely as a dietary supplement, could be considered as a serious therapeutic option for preventing, slowing, or halting AD progression.

4328- VitB5,    Pantethine
- Review, AD, NA
*BBB↝, BBB: not penetrant, but cysteamine (metabolite) is penetrant
*LDL↓, Pantethine has reduced total and LDL cholesterol though effects have been modest.
*lipid-P↓, Therapeutic Lifestyle Change (TLC) diet alone did not significantly affect lipid profiles but when combined with pantethine supplementation, significantly decreased lipid levels.
*AST↓, significantly reduced levels of liver enzymes (AST reduced from 66 to 33 IU/L, and ALT reduced from 113 to 51 IU/L, or by 58%)
*ALAT↓,
*TGF-β↓, mean serum TGF-β level was significantly decreased
*adiP↑, while the mean serum level of high molecular adiponectin was increased.
*Inflam↓, inflammation was improved,
TumCG↓, mouse model of ovarian tumor, pantethine treatment (750 mg/kg/day, i.p.) for 4 weeks resulted in slower tumor progression,
FASN↓, Pantethine inhibits fatty acid synthase (FAS). Inhibition of FAS activity has been shown to be cytotoxic to human cancer cells in vitro and in vivo [17].


Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

FASN↓, 1,  

Cell Death ⓘ

Apoptosis?, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Barriers & Transport ⓘ

BBB↝, 1,  

Immune & Inflammatory Signaling ⓘ

M1↑, 1,   M2 MC↑, 1,  

Drug Metabolism & Resistance ⓘ

RadioS↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

TMAO↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 2,   lipid-P↓, 3,   ROS↓, 2,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

adiP↑, 1,   ALAT↓, 1,   AMPK↑, 1,   LDL↓, 1,   NADPH↓, 1,  

Cell Death ⓘ

iNOS↓, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Migration ⓘ

TGF-β↓, 2,   TJ↝, 1,  

Barriers & Transport ⓘ

BBB↝, 8,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 3,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   monoA↑, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   Dose↝, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,  

Functional Outcomes ⓘ

cognitive↓, 1,   cognitive↑, 2,   memory↑, 2,   Mood↑, 1,   neuroP↑, 3,   toxicity∅, 1,  
Total Targets: 35

Scientific Paper Hit Count for: BBB, Blood-Brain Barrier Permeability
2 Vitamin B5,Pantothenic Acid
1 Silver-NanoParticles
1 Acetyl-l-carnitine
1 Bacopa monnieri
1 Choline
1 Myrrh
1 Quercetin
1 Rosmarinic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1123  State#:%  Dir#:4
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