CRM Cancer Research Results

CRM, Calorie restriction mimetics (CRMs): Click to Expand ⟱

Source:

Type:

Calorie restriction mimetics (CRMs) are compounds that appear to mimic some of the biochemical effects of caloric restriction without the need to actually reduce caloric intake.

-Resveratrol:Known for activating sirtuins (e.g., SIRT1)
-Curcumin
-Quercetin
-EGCG
-Spermidine
-Fisetin
-Berberine
-Pterostilbene
-Hydroxytyrosol
-Sulforaphane
-Cinnamaldehyde
-Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN)
-Alpha-Ketoglutarate (AKG)
-Rapamycin (Sirolimus

Scientific Papers found: Click to Expand⟱

5782-

Sper,

Cardioprotection and lifespan extension by the natural polyamine spermidine

in-vivo,

Nor,

mice

cardioP↑, Our results suggest a new and feasible strategy for the protection from cardiovascular disease.
eff↓, Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes.
AntiAge↑, Spermidine extends the lifespan of wild-type C57BL/6 mice. prolonged median lifespan by ~10%
BioAv↑, permidine-fed animals displayed increased circulating spermidine levels, confirming its systemic bioavailability
CRM↝, mass composition were similar in spermidine-fed and control groups (Supplementary Fig. 2), excluding the possibility that polyamine supplementation extends lifespan by inducing a calorically-restricted state13.

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

CRM↝, 1,

Drug Metabolism & Resistance ⓘ

BioAv↑, 1, eff↓, 1,

Functional Outcomes ⓘ

AntiAge↑, 1, cardioP↑, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: CRM, Calorie restriction mimetics (CRMs)

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells