MKP1 Cancer Research Results

MKP1, MAP kinase phosphatase 1: Click to Expand ⟱
Source:
Type:
MKP-1 and MKP-2 belong to the dual-specificity phosphatase family and are key regulators of MAPK signaling pathways (including ERK, JNK, and p38), which are central to cell proliferation, differentiation, and apoptosis.
-By dephosphorylating MAPKs, these phosphatases help maintain signaling homeostasis and protect cells against excessive or prolonged MAPK activation that could lead to cell death or uncontrolled proliferation.

-MKP-1 is frequently upregulated in various cancers, including breast, lung, and ovarian cancers, where it may serve as a feedback inhibitor of MAPK pathways.
- In some studies, high MKP-1 levels have been linked to resistance to chemotherapy and radiotherapy, as enhanced deactivation of MAPKs can reduce apoptosis in response to treatment-induced stress.
Scientific Papers found: Click to Expand⟱
4508- GLA,  aLinA,    α-Linolenic and γ-linolenic acids exercise differential antitumor effects on HT-29 human colorectal cancer cells
- in-vitro, Colon, HT29
Apoptosis↑, *Inflam↓, AntiCan↑, lipid-P↑, COX2↝, MKP1↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

lipid-P↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   MKP1↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↝, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: MKP1, MAP kinase phosphatase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1225  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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