homoC Cancer Research Results

homoC, homocysteine: Click to Expand ⟱
Source:
Type:
Homocysteine is a sulfur-containing amino acid produced during the metabolism of methionine. Elevated homocysteine levels and alterations in its metabolic enzymes have been associated with various pathological processes, including oxidative stress, DNA damage, and inflammation.
-Elevated plasma homocysteine levels (hyperhomocysteinemia) are a well‐established risk factor for cardiovascular diseases.
-Some studies have suggested that high levels of homocysteine might be associated with an increased risk of certain cancers.
-Vitamins like folate, B6, and B12 are key regulators of homocysteine metabolism, some research has examined whether supplementation might modulate cancer risk. However, clinical outcomes have been mixed and further research is needed.

-Various clinical trials have shown that the oral supplementation of folic acid, B6, and B12 vitamins significantly lowers circulating homocysteine levels.
Scientific Papers found: Click to Expand⟱
2174- FA,  VitB12,   
- Analysis, Var, NA
homoC↓, Vitamin B12 and folic acid are required for the remethylation reaction of homocysteine
eff↑, Homocysteine has been reported to be increased in a number of cancers includinghead and neck cancers,breast cancers,prostate cancers and colon cancers.
eff↑, Vitamin B12 and folate levels are significantly decreased in cancer patients.
eff↑, homocysteine levels are positively associated with proliferation rates of cells in a variety of tumors including head and neck and breast cancers [2] as well as with oxidative damage to cells
eff↝, cysteine may act as prooxidant agent that causes DNA oxidative damage as a result of the over production of free radicals and hydrogen peroxide ,leading to gene mutation and subsequent cancer development
homoC↝, It was observed that mean homocysteine levels were significantly increased almost double in cancer patients when compared to control subjects
other?, In the high homocysteine group Vitamin B12 was found to be significantly decreased

4075- FA,    Folic acid, ageing, depression, and dementia
- Review, AD, NA
*Mood↑, Folate deficiency is associated with depression and dementia
*cognitive↑, Impaired folate metabolism may result in a pattern of cognitive dysfunction that resembles ageing
*other↝, The duration of folate deficiency and of its treatment is as important as the degree of deficiency and the dose of folic acid
*memory↑, 38 folate deficient elderly subjects with depression, lethargy, and memory impairment, folinic acid 50 mg per week for 120 days significantly improved visuomotor performance, visuospatial memory, logical reasoning, associative memory, and activities
*QoL↑,
*homoC↝, confirmed neuropathologically in 76 patients in whom higher plasma homocysteine was associated with a more rapid atrophy of the medial temporal lobes over a three year period
*other↝, impact of folate is slow and cumulative over many months, perhaps because blood-brain barrier mechanisms limit entry to the brain.
*Dose↝, Small doses over the long term may be preferable to larger doses in the short or long term


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

homoC↓, 1,   homoC↝, 1,  

Transcription & Epigenetics ⓘ

other?, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 3,   eff↝, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

homoC↝, 1,  

Transcription & Epigenetics ⓘ

other↝, 2,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   memory↑, 1,   Mood↑, 1,   QoL↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: homoC, homocysteine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1257  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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