HSPs Cancer Research Results

HSPs, Heat shock proteins: Click to Expand ⟱
Source:
Type:
Heat shock proteins (HSPs) are a diverse group of molecular chaperones that assist in proper protein folding, stabilization of proteins against aggregation, and protein trafficking. In cancer, HSPs are often overexpressed, which can help tumor cells survive the stressful conditions present in the tumor microenvironment (such as hypoxia, oxidative stress, and nutrient deprivation).

-Overexpression: Many cancers exhibit high levels of HSPs compared to their normal tissue counterparts. Overexpression of chaperones like HSP27, HSP70, and HSP90 is common in various tumors.
Scientific Papers found: Click to Expand⟱
3687- Ash,    Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives
- Review, AD, NA
*Aβ↓, *tau↓, *HSPs↝, *antiOx↑, *ROS↓, *Inflam↓, *neuroP↑, *cognitive↑, *NF-kB↓, *HO-1↑, *memory↑, *AChE↓, *BChE↓, *ChAT↑, *Ach↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   HO-1↑, 1,   ROS↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,  

Protein Folding & ER Stress ⓘ

HSPs↝, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BChE↓, 1,   ChAT↑, 1,   tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 15

Scientific Paper Hit Count for: HSPs, Heat shock proteins
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1272  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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