XO Cancer Research Results

XO, xanthine oxidase: Click to Expand ⟱
Source:
Type:
xanthine oxidase The relationship between XO (xanthine oxidase) and Alzheimer’s disease (AD) is an emerging topic in neurodegenerative research, mainly because of XO's role in oxidative stress and inflammation, which are both key features in AD pathology.
-Studies suggest oxidative stress from XO may increase Aβ aggregation and promote tau phosphorylation, both critical to AD progression.
Scientific Papers found: Click to Expand⟱
7848- ISQ,    Review of anticancer mechanisms of isoquercitin
- Review, Var, NA
BioAv↑, This compound presents similar therapeutic profiles to quercetin but with superior bioavailability, resulting in increased efficacy compared to the aglycone form.
eff↑,
*antiOx↓, pharmacological effects including antioxidant, antiproliferative, anti-inflammatory, anti-hypertensive, and anti-diabetic.
TumCP↓,
*Inflam↓,
*AntiDiabetic↑,
lipid-P↓, The protective effects of IQ in cancer may be due to actions on lipid peroxidation.
*toxicity↓, Flavonoids are a group of polyphenolic compounds and as a part of the human diet, they have very low toxicity in addition to various beneficial health effects
*Half-Life↝, Human "Juice mix" Quercitin - 216 ± 96 mins
*Half-Life↑, Human Shallot flesh Isoquercitin 15 13980 ± 30
*XO↝, IQ exerts antioxidative effects by inhibiting lipid peroxidation via interference with enzyme activity (xanthine oxidase), chelation of redox-active metals, increased absorption of vitamin C, and direct scavenging of ROS
*IronCh↝,
*VitC↑,
*ROS↓,
β-catenin/ZEB1↓, IQ for example, acts directly by inhibiting the nuclear translocation of β-catenin protein and exhibits significant anti-proliferative effects on glioblastoma cells
Casp3↑, IQ activated caspase-3, 8, and 9 and reduced the mitochondrial membrane potential.
Casp8↑,
Casp9↑,
MMP↓,
p‑ERK↓, IQ inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) and promoted the phosphorylation of c-Jun N-terminal kinase (JuNK).
p‑cJun↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

lipid-P↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cJun↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   eff↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   ROS↓, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Half-Life↑, 1,   Half-Life↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   toxicity↓, 1,  
Total Targets: 10

Scientific Paper Hit Count for: XO, xanthine oxidase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1353  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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