ARE Cancer Research Results

ARE, antioxidant responsive element (ARE): Click to Expand ⟱
Source:
Type:
antioxidant responsive element (ARE)
ARE in Normal Cells: Protective Role
ARE-regulated genes include NQO1, HO-1, GCLM, GCLC, and various glutathione S-transferases (GSTs).
-Detoxify reactive oxygen species (ROS)
-Agents like sulforaphane (from broccoli) can activate ARE in healthy cells to prevent cancer initiation.
-overactivation in cancer cells aids cancer survival, growth, resistance
Scientific Papers found: Click to Expand⟱
6417- RES,  CUR,    Curcumin and Resveratrol Synergy: A Multi-Target Strategy Against Neurodegenerative Disease Pathology
- Review, AD, NA
*neuroP↑, synergistic approach with curcumin and resveratrol represents a promising strategy for developing novel neuroprotective agents for a range of neurological disorders.
*NRF2↝, compounds operate through multiple molecular pathways, including the modulation of the Nrf2/ARE signalling pathway, inhibition of NF-κB, and regulation of key proteins involved in amyloid-beta plaque formation and tau phosphorylation.
*ARE↝,
*NF-kB↓,
*Aβ↓,
*ROS↓, combined use has demonstrated enhanced efficacy in mitigating oxidative stress and neuroinflammation in various preclinical models.
*Inflam↓,
*BioAv↓, major challenges, such as poor bioavailability, and discusses advanced delivery strategies like nanomedicine to enhance their efficacy


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ARE↝, 1,   NRF2↝, 1,   ROS↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 8

Scientific Paper Hit Count for: ARE, antioxidant responsive element (ARE)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1354  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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