ADAM10 Cancer Research Results

ADAM10, A Disintegrin And Metalloproteinase Domain-Containing Protein 10: Click to Expand ⟱
Source:
Type:
ADAM10 (A Disintegrin And Metalloproteinase Domain-Containing Protein 10) plays a critical protective role in Alzheimer’s disease (AD) due to its function as an α-secretase, an enzyme involved in the non-amyloidogenic processing of the amyloid precursor protein (APP).
-By preventing Aβ accumulation, ADAM10 indirectly reduces amyloid plaques.br> -Downregulation of ADAM10 is observed in AD brains.
-ADAM10 levels are especially diminished in individuals with an APOE4 genotype
Scientific Papers found: Click to Expand⟱
3857- CUR,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
*Inflam↓, curcumin, a natural component extracted from the plant Curcuma longa that presents anti-inflammatory, antioxidant, and copper and iron chelation properties
*antiOx↑,
*IronCh↑,
*BBB↑, can easily penetrate the blood–brain barrier (BBB), and was suggested as a promising therapy for AD
*ADAM10↝, Curcumin conjugated with isoleucine, phenylalanine or valine at both extremities—but not curcumin alone or its metabolite tetrahydro-curcumin—was able to enhance ADAM10 protein expression

7833- GA,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, Gallic acid (3,4,5-trihydroxybenzoic acid) showed neuroprotective activity against AD in various roden
*Dose↝, gallic acid (20 or 30 mg/kg) improved the cognitive impairments no matter it was administrated from the early (4 months), middle (9 months) or late-stage (12 months) of AD pathology
*ADAM10↝, related mechanisms involved modulation of the activity of α-secretase (ADAM10) and βsecretase (BACE-1) to inhibit the amyloidogenic cleavage of APP, disruption of the salt bridge between Aβ to suppress its aggregatio
*BACE/β-secretase↓,
*cl‑APP↓,
*Aβ↓,
*Ca+2↓, improvement of synaptic plasticity, as well as inhibition of Ca2+ influx, oxidative stress, and neuroinflammation.
*ROS↓,
*NeuroI↓,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NeuroI↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Migration(tgid=13) ⓘ

cl‑APP↓, 1,   Ca+2↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10↝, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 13

Scientific Paper Hit Count for: ADAM10, A Disintegrin And Metalloproteinase Domain-Containing Protein 10
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1368  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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