CYP2A3/CYP2A6 Cancer Research Results

CYP2A3/CYP2A6, CYP2A3/CYP2A6: Click to Expand ⟱
Source:
Type:
CYP2A3 is a member of the cytochrome P450 superfamily and is the rat ortholog most closely related to human CYP2A6. It functions as a phase I xenobiotic-metabolizing enzyme, catalyzing the oxidative metabolism of small, often volatile or tobacco-related compounds.
CYP2A3 is widely used in rat toxicology and carcinogenesis studies as a surrogate to understand:
-Human CYP2A6-mediated cancer risk
-Tobacco-related lung carcinogenesis

Inhibition or downregulation of CYP2A3 in animal models often reduces carcinogen activation and tumor incidence, supporting its functional role in cancer initiation.
Scientific Papers found: Click to Expand⟱
6168- Cin,    Mechanisms of Herb-Drug Interactions Involving Cinnamon and CYP2A6: Focus on Time-Dependent Inhibition by Cinnamaldehyde and 2-Methoxycinnamaldehyde
- Analysis, Nor, NA
*CYP2A3/CYP2A6↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

CYP2A3/CYP2A6↝, 1,  
Total Targets: 1

Scientific Paper Hit Count for: CYP2A3/CYP2A6, CYP2A3/CYP2A6
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1408  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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