miR-375 Cancer Research Results

miR-375, miR-375: Click to Expand ⟱
Source:
Type:

miR-375 is a regulatory microRNA that generally functions as a tumour suppressor in head-and-neck and HPV-associated squamous cell carcinomas. It can suppress oncogenic transcripts involved in proliferation, survival, invasion, and extracellular-matrix degradation, including AEG-1/MTDH, IGF1R, JAK2, and YAP1. miR-375 may also directly or indirectly reduce HPV16/18 E6 and E7 expression, thereby supporting p53 and RB tumour- suppressor activity. miR-375 is frequently downregulated in these cancers; therefore, restoration or increased expression is generally considered the favourable direction in this context. Effects may differ by cancer type.



Scientific Papers found: Click to Expand⟱
6977- Form,    Differential ability of formononetin to stimulate proliferation of endothelial cells and breast cancer cells via a feedback loop involving MicroRNA-375, RASD1, and ERα
- in-vitro, BC, MCF7 - in-vitro, BC, BT474 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs
*Apoptosis↓, miR-375↝, p‑Akt↑, Bcl-2↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-375↝, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↑, 1,   Bcl-2↑, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: miR-375, miR-375
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1522  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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