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Ferroportin (FPN; gene symbol
SLC40A1) is the principal cellular iron-export protein. It
transports iron out of cells and is negatively regulated by hepcidin, which
promotes ferroportin internalization and degradation. In many cancers,
reduced ferroportin expression decreases iron export, increases intracellular
iron retention, and may support proliferation and tumour progression.
Therefore, FPN ↓ is commonly tumour-promoting, while
FPN ↑ generally lowers intracellular iron; however,
increased iron export may also reduce ferroptosis sensitivity. Record
expression, protein abundance, or iron-export activity according to the
specific study.
Gene reference;
Cancer and iron review.
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