FPN Cancer Research Results

FPN, Ferroportin: Click to Expand ⟱
Source:
Type: Biomarker

Ferroportin (FPN; gene symbol SLC40A1) is the principal cellular iron-export protein. It transports iron out of cells and is negatively regulated by hepcidin, which promotes ferroportin internalization and degradation. In many cancers, reduced ferroportin expression decreases iron export, increases intracellular iron retention, and may support proliferation and tumour progression. Therefore, FPN ↓ is commonly tumour-promoting, while FPN ↑ generally lowers intracellular iron; however, increased iron export may also reduce ferroptosis sensitivity. Record expression, protein abundance, or iron-export activity according to the specific study. Gene reference; Cancer and iron review.



Scientific Papers found: Click to Expand⟱
6891- Fer,    Iron oxide nanoparticles inhibit tumor growth by ferroptosis in diffuse large B-cell lymphoma
- vitro+vivo, lymphoma, NA
TumCG↓, Importantly, IONs have demonstrated a significant inhibitory effect on the growth of tumors, including hematopoietic and lymphoid tumors, such as leukemia.
Ferroptosis↑, we further demonstrated the effect of IONs on inhibiting the growth of diffuse large B-cell lymphoma (DLBCL) cells by enhancing ferroptosis-mediated cell death.
i-Iron↑, IONs treatment caused an accumulation of intracellular ferrous iron and the onset of lipid peroxidation in DLBCL cells as well as the suppressed expression of anti-ferroptosis protein Glutathione Peroxidase 4 (GPX4), thereby leading to increased ferr
lipid-P↑,
GPx4↓, expression of ferroptosis negative regulators such as GPX4 and SLC40A1 was significantly decreased after IONs treatment
ROS↑, Mechanistically, IONs increased cellular lipid peroxidation through the generation of ROS via the Fenton reaction
Fenton↑,
TfR1/CD71↝, regulating the iron metabolism-related proteins, such as ferroportin (FPN) and transferrin receptor (TFR), which elevated the intracellular labile iron pool (LIP).
FPN↝,
LIP↑,
TumCP↓, IONs inhibited cell proliferation while induced apoptosis in DLBCL
Apoptosis↑,
TumCG↓, IONs inhibited the growth of xenograft tumor


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

FPN↝, 1,   LIP↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Fenton↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   i-Iron↑, 1,   lipid-P↑, 1,   ROS↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

TfR1/CD71↝, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Ferroptosis↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 2,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: FPN, Ferroportin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1536  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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