OS Cancer Research Results

OS, overall survival: Click to Expand ⟱
Source:
Type:
Overall survival
Scientific Papers found: Click to Expand⟱
5324- ALC,    The anti-wasting effects of L-carnitine supplementation on cancer: experimental data and clinical studies
- Review, Var, NA
*cachexia↓, The results of this process favored L-carnitine supplementation in patients with cancer-related cachexia.
*Apoptosis↓, inhibiting apoptosis or reversing inflammatory processes.
*Inflam↓,
QoL↑, This treatment increased plasma-free carnitine concentrations and significantly improved fatigue, which was assessed using the functional assessment of cancer therapy, fatigue, and quality of life questionnaire, as well as quality-of-life measu
Dose↝, placebo-controlled trial, in which 2 g per day of LC was administrated orally for four weeks among eligible patients.
Weight↑, advanced pancreatic cancer received either LC (4 g/day orally) or a placebo for 12 weeks. The results showed that body mass index, nutritional status (body cell mass and body fat), and quality-of-life parameters increased
OS↝, There was an insignificant increase in overall survival, a decline in length of hospital stays, and decrease in fatigue among the LC-treated patients.
fatigue↓,
eff↝, some dietary factors, such as food intake restriction and intake of LC and certain micronutrients (vitamin C, vitamin B6, and iron, which are required as cofactors for endogenous LC biosynthesis) may have some effects on the efficacy of LC sup

5736- Buty,    Clinical and pharmacologic study of tributyrin: an oral butyrate prodrug
- Trial, Var, NA
Dose↝, tributyrin at doses from 150 to 200 mg/kg three times daily.
BioAv↝, median butyrate concentration of 52 microM was obtained but there was considerable interpatient variability
toxicity↓, Tributyrin is well tolerated and levels associated with in vitro activity are achieved with three times daily dosing
OS↝, There were four patients with prolonged disease stabilization ranging from 3 to 23 months; median progression-free survival was 55 days.


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   Dose↝, 2,   eff↝, 1,  

Functional Outcomes ⓘ

fatigue↓, 1,   OS↝, 2,   QoL↑, 1,   toxicity↓, 1,   Weight↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

Apoptosis↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Functional Outcomes ⓘ

cachexia↓, 1,  
Total Targets: 3

Scientific Paper Hit Count for: OS, overall survival
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:229  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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