P-gp Cancer Research Results

P-gp, permeability-glycoprotein: Click to Expand ⟱
Source:
Type:
P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), is a membrane protein that plays a crucial role in the transport of various substances across cellular membranes. It is part of the ATP-binding cassette (ABC) transporter family.
P-glycoprotein is often overexpressed in a variety of cancers, including breast cancer, lung cancer, leukemia, and ovarian cancer.

- The overexpression of P-glycoprotein (P-gp), is widely considered as an important reason for the MDR (multidrug resistance).
Scientific Papers found: Click to Expand⟱
5856- CAP,    Potential of capsaicin as a combinatorial agent to overcome chemoresistance and to improve outcomes of cancer therapy
- Review, Var, NA
ChemoSen↑, has garnered significant interest for its potential role as a combinatorial and chemosensitizing agent in cancer therapy
Apoptosis↑, CAPS enhanced the efficacy of various anticancer agents by promoting apoptosis, modulating autophagy and inhibiting angiogenesis, tumor growth, and metastasis.
TumAuto↑,
angioG↓,
TumCG↓,
TumMeta↓,
P-gp↝, CAPS modulated critical regulators of chemoresistance, such as P-glycoprotein (P-gp), extracellular signal-regulated kinase (ERK), nuclear factor-kappa B (NF-κB) pathway, and signal transducer and activator of transcription 3 (STAT3) pathway
ERK↝,
NF-kB↝,
STAT3↝,
eff↑, combination with chemotherapeutic agents, CAPS has been shown to improve treatment efficacy at lower drug concentrations.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↝, 1,   STAT3↝, 1,   TumCG↓, 1,  

Migration ⓘ

TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Barriers & Transport ⓘ

P-gp↝, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↝, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: P-gp, permeability-glycoprotein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:232  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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