PI3K Cancer Research Results

PI3K, Phosphatidylinositide-3-Kinases: Click to Expand ⟱
Source: HalifaxProj(inhibit) CGL-CS
Type:
Phosphatidylinositol 3-kinase (PtdIns3K or PI3K) is a family of enzymes that play a crucial role in cell signaling pathways, particularly in the regulation of cell growth, survival, and metabolism. The PI3K pathway is one of the most frequently altered pathways in human cancer. Inhibition of the PI3K pathway has been explored as a therapeutic strategy for cancer treatment. Several PI3K inhibitors have been developed and are currently being tested in clinical trials. These inhibitors can target specific components of the pathway, such as PI3K, AKT, or mTOR.

Class I phosphoinositide 3-kinase (PI3K)
Class III PtdIns3K
In contrast to the class III PtdIns3K as a positive regulator of autophagy, class I PI3K-AKT signaling has an opposing effect on the initiation of autophagy.

PI3K inhibitors include:
-Idelalisib , Copanlisib, Alpelisib
-LY294002?
-Wortmannin: potent PI3K inhibitor, has some associated toxicity.
-Quercetin:
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
Scientific Papers found: Click to Expand⟱
285- ALA,  HCA,    Tolerance of oral lipoid acid and hydroxycitrate combination in cancer patients: first approach of the cancer metabolism research group
- Human, Var, NA
PI3K↝,
AMPK↝,
TumCG↓,
*toxicity↓, No hepatic toxicity found, no weight loss, no hypoglycemia
Weight∅,

6007- CGA,    A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer
- Review, CRC, NA
antiOx↑, They are best known for their high concentration in coffee and other dietary sources and the antioxidant properties that they exhibit.
TumCCA↑, this review aims to enable a better understanding of the modes of action of chlorogenic acids in combating carcinogenesis, with a focus on cell cycle arrest, the induction of apoptosis, and the modulation of Wnt, Pi3K/Akt, and MAPK
Apoptosis↑,
Wnt↝,
PI3K↝,
MAPK↝,
ROS↓, CGAs have demonstrated significant reactive oxygen species (ROS) scavenging potential through two direct mechanisms: hydrogen atom transfer (HAT) and radical adduct formation (RAF)
BioAv↝, bioavailability of CGAs in humans involves a complex process of digestion, absorption, and metabolism (Figure 7), primarily occurring within the stomach, small and large intestines, governed by the interplay between host enzymes and gut microbiota
P53↑, ↑ p53, ↑ p21, ↑ p18, ↑ CDKI, ↓ cyclin-D1, ↑ G1 cell population
P21↑,
CDK1↑,
Ki-67↓, ↓ Ki-67
Ca+2↑, ↑ Ca2+ levels Caco-2—cell culture
p‑Akt↓, ↓ p-AKT, ↓ mTOR
mTOR↓,
GSH↑, ↑ GSH, ↑ Nrf-2, ↑ HO-1 Caco-2—cell culture
NRF2↑,
HO-1↑,
COX2↓, ↓ COX-2, ↓ TNF-α, ↓ IL-1β, ↓ IL-6 LPS-induced SW480—cell culture
TNF-α↓,
IL1β↓,
IL6↓,

15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, involve NF-κB, Akt, androgen receptors, and apoptosis pathways.
Akt↝, see figure 5
AR↝,
Apoptosis↝,
Bcl-2↝,
Casp3↝,
BAX↝,
P21↝,
ROS↝,
Bcl-xL↝,
JNK↝,
MMP2↝,
P53↝,
PSA↝,
VEGF↝,
COX2↝,
cycD1/CCND1↝,
EGFR↝,
IL6↝,
β-catenin/ZEB1↝,
mTOR↝,
NRF2↝,
AP-1↝,
Cyt‑c↝,
PI3K↝,
PTEN↝,
Cyc↝,
TNF-α↝,

4800- Lyco,    Recent insights on pharmacological potential of lycopene and its nanoformulations: an emerging paradigm towards improvement of human health
- Review, Var, NA
*antiOx↑, It is a potent antioxidant and free radical scavenger owing to the presence of 13 carbon–carbon double bonds, out of which 11 are conjugated and the remaining 2 are non-conjugated.
Keap1↝, many biological effects on different types of cancers like prostate, breast, skin, and oral cancer by targeting the Keap1-NF-kB, Keap1-Nrf 2 and PI3K/AKT/m-TOR signalling pathway.
NF-kB↝,
NRF2↝,
PI3K↝,
Akt↝,
mTOR↝,
*GutMicro↑, lycopene also has the ability to modify the gut microbiome

6047- SeNPs,  CGA,    Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT axis
- in-vitro, Nor, NA
*Dose↝, chlorogenic acid, a polyphenol commonly found in herb, had been effectively conjugated with human serum albumin and coated on selenium nanoparticles (Se NPs) to create CHSe NPs.
*SOD↑, CHSe NPs exhibited superoxide dismutase(SOD) like and glutathione peroxidase(GPX) like activities, effectively scavenging various types of reactive oxygen species (ROS), and inhibited the inflammatory response of macrophages.
*GPx↑,
*ROS↓,
*Inflam↓,
*MAPK↝, CHSe NPs synergistically exert antioxidant and anti-inflammatory effects by regulating the MAPK signaling pathway and PI3K-Akt signaling pathway, showing enormous potential in the treatment of ALI.
*PI3K↝,

4203- SIL,    Unlocking the Neuroprotective Potential of Silymarin: A Promising Ally in Safeguarding the Brain from Alzheimer’s Disease and Other Neurological Disorders
- Review, NA, NA
*MAPK↝, Silymarin utilizes a range of molecular mechanisms, including modulation of MAPK, AMPK, NF-κB, mTOR, and PI3K/Akt pathways
*AMPK↝,
*NF-kB↓,
*mTOR↝,
*PI3K↝,
*Akt↝,
*BioAv↝, silymarin faces challenges related to bioavailability and aqueous solubility, hindering its development as a clinical drug
*memory↑, silymarin dose-dependently improves the memory and expression of BDNF in TBI-induced mice along with a significant reduction in the level of glutamate and TNF-α, affirming that silymarin could be a potential therapeutic agent for addressing cognitiv
*BDNF↑,
*TNF-α↓,

2281- VitK2,    The biological responses of vitamin K2: A comprehensive review
- Review, Var, NA
*ROS↓, VitK1 and MK-4 prevent oxidative cell death by blocking the activation of 12-LOX and ROS generation
*12LOX↓,
*NF-kB↓, VitK2 modulates osteoblast and osteoclast formation and activity via downregulation of basal and cytokine-induced NF-κB activation
*BMD↑, strengthens bone construction
*hepatoP↑, VitK2 significantly increased serum albumin levels with concurrent reduction of the levels of alanine and aspartate aminotransferases, suggesting that VitK2 enhances liver regeneration.
cycD1/CCND1↓, figure 5
PKCδ↓,
STAT3↓,
ERK↑,
MAPK↓,
ROS↑,
PI3K↝,
Akt↝,
Hif1a↝,
*neuroP↑, An increasing body of evidence suggests the possible role of VitK supplementation as a novel neuroprotective strategy in the maintenance of nerve integrity and normal brain function, including cognition and behavior


Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 1,   HO-1↑, 1,   Keap1↝, 1,   NRF2↑, 1,   NRF2↝, 2,   ROS↓, 1,   ROS↑, 1,   ROS↝, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↝, 1,  

Cell Death ⓘ

Akt↝, 3,   p‑Akt↓, 1,   Apoptosis↑, 1,   Apoptosis↝, 1,   BAX↝, 1,   Bcl-2↝, 1,   Bcl-xL↝, 1,   Casp3↝, 1,   Cyt‑c↝, 1,   JNK↝, 1,   MAPK↓, 1,   MAPK↝, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,   P53↝, 1,  

Cell Cycle & Senescence ⓘ

CDK1↑, 1,   Cyc↝, 1,   cycD1/CCND1↓, 1,   cycD1/CCND1↝, 1,   P21↑, 1,   P21↝, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   mTOR↓, 1,   mTOR↝, 2,   PI3K↝, 5,   PTEN↝, 1,   STAT3↓, 1,   TumCG↓, 1,   Wnt↝, 1,  

Migration ⓘ

AP-1↝, 1,   Ca+2↑, 1,   Ki-67↓, 1,   MMP2↝, 1,   PKCδ↓, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↝, 1,   Hif1a↝, 1,   VEGF↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   COX2↝, 1,   IL1β↓, 1,   IL6↓, 1,   IL6↝, 1,   NF-kB↝, 2,   PSA↝, 1,   TNF-α↓, 1,   TNF-α↝, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↝, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,  

Clinical Biomarkers ⓘ

AR↝, 1,   EGFR↝, 1,   IL6↓, 1,   IL6↝, 1,   Ki-67↓, 1,   PSA↝, 1,  

Functional Outcomes ⓘ

Weight∅, 1,  
Total Targets: 66

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GPx↑, 1,   ROS↓, 2,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   AMPK↝, 1,  

Cell Death ⓘ

Akt↝, 1,   MAPK↝, 2,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↝, 1,   PI3K↝, 2,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   NF-kB↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   Dose↝, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   GutMicro↑, 1,  

Functional Outcomes ⓘ

hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 22

Scientific Paper Hit Count for: PI3K, Phosphatidylinositide-3-Kinases
2 Chlorogenic acid
1 Alpha-Lipoic-Acid
1 HydroxyCitric Acid
1 Curcumin
1 Ursolic acid
1 Lycopene
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:252  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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