PI3k/Akt/mTOR Cancer Research Results

PI3k/Akt/mTOR, Phosphoinositide 3-kinase/Protein Kinase B/ mammalian target of rapamycin: Click to Expand ⟱

Source:

Type:

The PI3K/Akt/mTOR signaling pathway is a critical regulator of cell growth, proliferation, survival, and metabolism.

In many cancers (such as breast, colorectal, lung, and endometrial cancers), the PI3K/Akt/mTOR pathway is often hyperactivated.

– This hyperactivation is frequently due to gene mutations (e.g., in PIK3CA), loss of PTEN, and amplification events that enhance the pathway’s activity.

– Increased activity is also observed via elevated levels of phosphorylated Akt and mTOR in tumors compared to normal tissues.

Scientific Papers found: Click to Expand⟱

245-

AL,

Allicin: a promising modulator of apoptosis and survival signaling in cancer

Review,

Var,

Fas↑, Bcl-2↓, BAX↑, PI3k/Akt/mTOR↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↓, *toxicity↓, Cyt‑c↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

PI3k/Akt/mTOR↝, 1,

Cell Death ⓘ

Apoptosis↓, 1, BAX↑, 1, Bcl-2↓, 1, Casp3↑, 1, Casp8↑, 1, Casp9↑, 1, Cyt‑c↑, 1, Fas↑, 1,
Total Targets: 9

Pathway results for Effect on Normal Cells:

Functional Outcomes ⓘ

toxicity↓, 1,
Total Targets: 1

Scientific Paper Hit Count for: PI3k/Akt/mTOR, Phosphoinositide 3-kinase/Protein Kinase B/ mammalian target of rapamycin

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells