BAX Cancer Research Results

BAX, Apoptosis regulator BAX: Click to Expand ⟱
Source:
Type: Proapototic protein
BAX is a member of the Bcl-2 gene family.
Pro-apoptotic protein that forms heterodimers with anti-apoptotic BCL2 proteins; involved in various cellular activities and regulated by p53; mediates the release of cytochrome c from mitochondria.
Scientific Papers found: Click to Expand⟱
5722- BF,    Bufalin exerts antitumor effects by inducing cell cycle arrest and triggering apoptosis in pancreatic cancer cells
- in-vitro, PC, PANC1
Apoptosis↑, TumCCA↑, HSP27↓, p‑Akt↓, proCasp3↑, proCasp9↑, Bcl-2↝, BAX↝, eff↑,
5728- BF,    Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action
- in-vitro, Lung, A549
TumCP↓, Apoptosis↑, TumCCA↑, Bcl-2↝, BAX↝, Cyt‑c↝, Casp3↝, PARP↝, P21↝, cycD1/CCND1↝, COX2↝, p‑VEGFR2↓, EGFR↓, Akt↓, NF-kB↓, p44↓,
130- CUR,    Maspin Enhances the Anticancer Activity of Curcumin in Hormone-refractory Prostate Cancer Cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
BAD↝, BAX↝, eff↑,
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
4795- Lyco,    Updates on the Anticancer Profile of Lycopene and its Probable Mechanism against Breast and Gynecological Cancer
- Review, BC, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↝, BAX↝, cycD1/CCND1↓, ERK↓, Akt↓, STAT3↓, NRF2↝, NF-kB↓, ITGB1↓, ITGA5↓, FAK↓, MMP9↓, EMT↓,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NRF2↝, 2,   ROS↝, 1,  

Cell Death ⓘ

Akt↓, 2,   Akt↝, 1,   p‑Akt↓, 1,   Apoptosis↑, 3,   Apoptosis↝, 1,   BAD↝, 1,   BAX↝, 5,   Bcl-2↝, 3,   Bcl-xL↝, 1,   Casp3↝, 2,   proCasp3↑, 1,   proCasp9↑, 1,   Cyt‑c↝, 2,   JNK↝, 1,  

Protein Folding & ER Stress ⓘ

HSP27↓, 1,  

DNA Damage & Repair ⓘ

P53↝, 2,   PARP↝, 1,  

Cell Cycle & Senescence ⓘ

Cyc↝, 1,   cycD1/CCND1↓, 1,   cycD1/CCND1↝, 2,   P21↝, 2,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 1,   mTOR↝, 1,   PI3K↝, 1,   PTEN↝, 1,   STAT3↓, 1,   TumCG↓, 1,  

Migration ⓘ

AP-1↝, 1,   FAK↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   MMP2↝, 1,   MMP9↓, 1,   p44↓, 1,   TumCP↓, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   EGFR↝, 1,   VEGF↝, 1,   p‑VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↝, 2,   IL6↝, 1,   NF-kB↓, 2,   NF-kB↝, 1,   PSA↝, 1,   TNF-α↝, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↝, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 2,  

Clinical Biomarkers ⓘ

AR↝, 1,   EGFR↓, 1,   EGFR↝, 1,   IL6↝, 1,   PSA↝, 1,  
Total Targets: 57

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: BAX, Apoptosis regulator BAX
2 Bufalin/Huachansu
2 Curcumin
1 Ursolic acid
1 Lycopene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:26  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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