Rho Cancer Research Results

Rho, Rho GTPases: Click to Expand ⟱
Source:
Type:
The Rho GTPases RhoA, Rac1, and Cdc42 are important regulators of cytoskeletal dynamics. small GTPase Ras homolog gene family member A (RHOA)
RHOA: Ras homolog family member A
Many in vitro and in vivo data indicate tumor-promoting effects of activated Rho GTPases, also tumor suppressive functions have been described.
In many cancers, RhoA and RhoC are often found to be overexpressed.
RhoB expression can be downregulated in certain cancers, which may contribute to tumor progression. Unlike RhoA and RhoC, RhoB is often considered a tumor suppressor, and its loss can lead to increased cell proliferation and survival.
-RhoA activity has been linked to the modulation of EMT, influencing both the disassembly of cell–cell junctions and the reorganization of the cytoskeleton necessary for migration.
-Elevated levels or hyperactivation of RhoA has been associated with poor prognosis in several cancers.


Scientific Papers found: Click to Expand⟱
7358- HibSad,    Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne
- Review, Var, NA
chemoPv↑, In this review, we discuss the chemopreventive properties and possible mechanisms of various H. sabdariffa extracts.
*ROS↓, PCA and HAs protected against oxidative damage induced by tert-butyl droperoxide (t-BHP) in rat primary hepatocytes
*other↝, HSE could be pursued as atherosclerosis chemopreventive agents as they inhibit LDL oxidation, foam cell formation, as well as smooth muscle cell migration and proliferation.
*hepatoP↑, extracts also offer hepatoprotection by influencing the levels of lipid peroxidation products and liver marker enzymes in experimental hyperammonemia.
*lipid-P↓,
Apoptosis↑, HAs and HPE were demonstrated to cause cancer cell apoptosis, especially in leukemia and gastric cancer.
*LDL↓, The anti-cholesterol action of 0.5% or 1% H. sabdariffa aqueous extracts (HSE) was confirmed in rabbits
RAS↓, PCA down-regulated the oncogenic Ras/Akt/NF-kB tumor progression pathway by targeting activation of the tumor suppressor RhoB, which in turn led to a reduction of matrix metalloproteinase
Akt↓,
NF-kB↓,
Rho↝,
MMPs↓,
*AntiDiabetic↑, H. SABDARIFFA EXTRACTS AND ANTIDIABETES
*Catalase↑, HSE or HPE significantly increased the activity of catalase and glutathione and reduced lipid peroxidation
*GSH↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

RAS↓, 1,  

Migration(tgid=13) ⓘ

MMPs↓, 1,   Rho↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GSH↑, 1,   lipid-P↓, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDL↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   hepatoP↑, 1,  
Total Targets: 8

Scientific Paper Hit Count for: Rho, Rho GTPases
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:273  State#:%  Dir#:4
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