survivin Cancer Research Results

survivin, BIRC5: Click to Expand ⟱
Source:
Type: antiapoptosis protein
Survivin, BIRC5 (Baculoviral IAP Repeat Containing 5) is a potent anti-apoptosis protein that is differentially expressed in cancer and therefore constitutes an important anti-cancer target [49]. Moreover, high expression of survivin plays important role in resistance to chemo- and radiotherapy and has been shown to be related to unfavorable outcome for medulloblastomas.
"Survivin" is a protein that plays a crucial role in regulating cell division and inhibiting apoptosis (programmed cell death). It is part of the inhibitor of apoptosis (IAP) family and is often overexpressed in various types of cancer.
Scientific Papers found: Click to Expand⟱
565- ART/DHA,    Artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably Suppresses Hepatocellular Carcinoma
STAT↓,
IL6↓,
pro‑Casp3↝,
Bcl-xL↝,
survivin↝,

4630- OLE,    Targeting resistant breast cancer stem cells in a three-dimensional culture model with oleuropein encapsulated in methacrylated alginate microparticles
- in-vitro, BC, NA
Bcl-2↓, OLE-mALG induced apoptosis through the decrease in anti-apoptotic Bcl-2 and an increase in pro-apoptotic Bax, caspase-3, and caspase-9 protein levels.
BAX↑,
Casp3↑,
Casp9↑,
Vim↓, Vimentin and Slug protein levels decreased after 200 µg/mL OLE-mALG treatment to 3D breast cancer culture, E-cadherin levels increased.
Slug↓,
E-cadherin↑,
CSCs↓, OLE-mALG treatment to CSC co-culture led to a decrease in proliferation by triggering p21/SURVIVIN expressions, and also resulted in an increase in stemness genes (OCT3/4/NANOG/SOX2).
P21↑,
survivin↝,
OCT4↑, OCT3/4 — ~ 27-fold increase . simultaneously up-regulating stemness-associated transcription factors — a complex phenotype that the authors interpret not as promoting tumorigenicity
Nanog↑, NANOG — ~ 10-fold increase
SOX4↑, SOX2 — ~ 4-fold increase


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Bcl-xL↝, 1,   Casp3↑, 1,   pro‑Casp3↝, 1,   Casp9↑, 1,   survivin↝, 2,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   Nanog↑, 1,   OCT4↑, 1,   STAT↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   Slug↓, 1,   SOX4↑, 1,   Vim↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: survivin, BIRC5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:299  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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