TJ Cancer Research Results

TJ, Tight junctions: Click to Expand ⟱
Source: HalifaxProj(promote)
Type:
Tight junctions (TJ) are specialized structures that form a barrier between epithelial cells, regulating the passage of substances between the cells and maintaining the integrity of tissue. They play a crucial role in maintaining cell polarity, tissue homeostasis, and the selective permeability of epithelial layers.

1.Overexpression of some claudins (e.g., claudin-1, -3, -4) in certain cancers is often associated with increased tumor aggressiveness and poor prognosis (protumor effects).
2.Downregulation or mislocalization of occludin and ZO proteins is generally linked to loss of cell–cell adhesion, EMT, and worse outcomes.
3.In contrast, loss of claudin-7 can remove its tumor suppressor functions, thereby facilitating invasion.

The expression and impact of tight junction components in cancer is an area of active research—each protein can have dual roles (protumor or tumor suppressive) based on the tumor type, the molecular context, and the stage of disease progression.
Scientific Papers found: Click to Expand⟱
6112- Chol,    Trimethylamine N-oxide induced cognitive impairment through disruption of blood-brain barrier by inhibiting TGF-β pathway
- in-vivo, AD, NA
*TMAO↑, (HFD) promotes cardiovascular disease, in part because it is rich in quaternary amines such as choline, carnitine, and lecithin, which are converted to trimethylamine (TMA) by the gut microbes and increase levels of circulating TMAO
*cognitive↓, TMAO induces cognitive impairment via disrupting the BBB. TMAO treatment induced cognitive impairment and disrupted the BBB integrity in mice
*BBB↝, TMAO has been reported to regulate blood-brain barrier (BBB) integrity and suppress the expression of tight junction proteins (TJs) in the microvasculature.
*TJ↝,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

TMAO↑, 1,  

Migration ⓘ

TJ↝, 1,  

Barriers & Transport ⓘ

BBB↝, 1,  

Functional Outcomes ⓘ

cognitive↓, 1,  
Total Targets: 4

Scientific Paper Hit Count for: TJ, Tight junctions
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:306  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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