TumCG Cancer Research Results

TumCG, Tumor cell growth: Click to Expand ⟱
Source:
Type:
Normal cells grow and divide in a regulated manner through the cell cycle, which consists of phases (G1, S, G2, and M).
Cancer cells often bypass these regulatory mechanisms, leading to uncontrolled proliferation. This can result from mutations in genes that control the cell cycle, such as oncogenes (which promote cell division) and tumor suppressor genes (which inhibit cell division).
Scientific Papers found: Click to Expand⟱
5616- NaHCO3,  DCA,    Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer
- vitro+vivo, BC, MDA-MB-231
OS↑, Survival was longest in mice administered bicarbonate-based therapies.
e-pH↑, This study reported that systemic bicarbonate buffered the extracellular pH in tumors to neutral levels (a pH of 7.2) and inhibited the spread of metastases which led to improved survival.
TumMeta↓,
eff↝, Urine pH in DCA treated mice was the same as measured in untreated mice.
TumCG↝, In our study, treating MDA-MB-231 tumor bearing mice with DCA and DB did not impact primary tumor growth.

5614- NaHCO3,    Targeting the Acidic Tumor Microenvironment: Unexpected Pro-Neoplastic Effects of Oral NaHCO3 Therapy in Murine Breast Tissue
- in-vivo, BC, NA
e-pH↑, Oral NaHCO3 therapy increases breast tumor pH in vivo from 6.68 ± 0.04 to 7.04 ± 0.09 and intracellular pH in breast epithelial organoids by ~0.15.
TumCG↝, Breast tumors develop with median latency of 85.5 ± 8.2 days in NaHCO3-treated mice vs. 82 ± 7.5 days in control mice.
TumCP↑, accelerates proliferation without net effect on breast cancer development or tumor growth.

5600- NaHCO3,    Acidosis and Cancer: from Mechanism to Neutralization
- Review, Var, NA
e-pH↑, During this work we observed in multiple systems that chronic ingestion of ad lib 200 mM sodium bicarbonate increases tumor pH and rarely affects growth of primary tumors, but potently inhibited experimental or spontaneous metastases (61).
TumCG↝,
eff↑, In mice bearing B-16 melanoma xenografts, treatment with bicarbonate synergized with the T-cell checkpoint inhibitors anti-CTLA4 antibody (ipilimumab) and anti PD-1.


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

TumCG↝, 3,  

Migration ⓘ

TumCP↑, 1,   TumMeta↓, 1,  

Cellular Microenvironment ⓘ

e-pH↑, 3,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   eff↝, 1,  

Functional Outcomes ⓘ

OS↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TumCG, Tumor cell growth
3 Bicarbonate(Sodium)
1 Dichloroacetate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:323  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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