GutMicro Cancer Research Results

GutMicro, Gut Microbiota: Click to Expand ⟱
Source:
Type:
Gut microbiome may affect responses to numerous forms of cancer therapy.
The gut microbiota plays a multifaceted role in cancer biology, influencing tumor development, progression, and patient prognosis. Dysbiosis and specific microbial populations have been linked to various cancers, with implications for patient outcomes. While the relationship between gut microbiota and cancer prognosis is an active area of research, it holds promise for the development of microbiome-based biomarkers and therapeutic strategies in oncology.


Scientific Papers found: Click to Expand⟱
4366- AgNPs,    Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles
- in-vivo, Nor, NA
*GutMicro↝, Findings suggest short-term exposure to AgNS or AgNC can lead to behavioral and gut microbiome changes.

4596- AgNPs,    Oral administration of silver nanomaterials affects the gut microbiota and metabolic profile altering the secretion of 5-HT in mice
- in-vivo, NA, NA
*GutMicro↝, decreased the diversity of gut microbiota in mice after short-term (14 days) exposure, while the microbial community tended to recover after long-term exposure (28 days),
*5HT↑, the gut metabolites significantly changed, showing increased 1H-indole-3-carboxylic acid and elevated levels of 5-HT in the gut and blood

306- AgNPs,    Cancer Therapy by Silver Nanoparticles: Fiction or Reality?
- Analysis, NA, NA
EPR↝, takes advantage of EPR
ROS↑, silver ions drive the formation of ROS, which triggers massive oxidative stress, thereby activating the cellular pathways leading to cell death
IL1↑, IL-1b
IL8↑, IL-8 mRNA levels
ER Stress↑,
MMP9↑, it has been shown that 20 nm AgNPs increase the MMP-9 secretion
MMP↓, loss of mitochondrial membrane potential and mitochondrial structural disorganization, were reported to accompany the AgNP-induced stres
Cyt‑c↑, cytochrome c release from the mitochondria into the cytoplasm and finally to apoptosis
Apoptosis↑,
Hif1a↑, AgNPs were shown to induce HiF-1α activation, thereby ultimately activating autophagy through the AMPK-mTOR pathway in PC-3 prostate cancer cells [89
BBB↑, AgNPs can affect the integrity of the blood–brain barrier and can cross this barrier in vitro through transcytosis
GutMicro↝, AgNP treatments might influence the composition of the gut microbiota,
eff↑, AgNPs are promising tools for targeted delivery
eff↑, the joint application of the nanoparticles and the HDAC inhibitor caused significantly increased ROS levels,
RadioS↑, idea to use AgNPs as radiosensitizers came along with the phenomenon that metals with high atomic numbers are capable of enhancing the effects of radiation

6101- Chol,    Effect of Choline Forms and Gut Microbiota Composition on Trimethylamine-N-Oxide Response in Healthy Men
- Human, Nor, NA
*TMAO↑, Choline serves as a dietary precursor for the gut microbial-generated trimethylamine (TMA) that is subsequently oxidized by the hepatic enzyme flavin-containing monooxygenase 3 (FMO3) to form (TMAO), a newly recognized risk marker for cardiovascular
*Dose↝, study meals consisted of 1 cup (237 mL) of tomato soup containing different forms of choline and provided approximately 600 mg of choline as choline bitartrate or phosphatidylcholine, compared to no choline control.
*GutMicro↝, We demonstrate for the first time that heightened TMAO response to choline bitartrate intake may largely be attributed to abundant lineages of Clostridium (in phylum Firmicutes) and may provide guidance to personalized therapeutic strategies in reduc

4673- CUR,    Curcumin and colorectal cancer: An update and current perspective on this natural medicine
- Review, CRC, NA
AntiCan↑, past few decades have overwhelmingly shown that curcumin exhibits a multitude of anti-cancer activities
GutMicro↝, Curcumin as a modulator of gut microbial environment

1791- LEC,    Vegetable lecithins: A review of their compositional diversity, impact on lipid metabolism and potential in cardiometabolic disease prevention
- Review, Nor, NA
*BioEnh↑, Firstly, the pre-emulsification of an oil with vegetable lecithin has been shown to increase the systemic bioavailability of certain fatty acids, without increasing total plasma lipid concentrations.
*antiOx↑, different lecithin from various sources (soy, rapeseed) or with differing PL compositions have been reported to exert varying antioxidant properties
*BioEnh↑, ported higher plasma alpha-linolenic acid (ALA) concentrations in the PL-emulsified group
*LDL↓, oybean PL in patients with primary hyperlipidemia has been reported to significantly reduce blood cholesterol levels
*HDL∅, while maintaining plasmatic HDL levels
*Obesity↓, potential of lecithin on the prevention and amelioration of obesity-related metabolic disorders
eff↑, lecithin derived from olive oil compared to that of other seed oils (sunflower, corn or soybean) as a platelet aggregation factor (PAF) antagonist
GutMicro↝, importance of gut microbiota on lipid metabolism and metabolic health renders obligatory that further research on the effect of vegetable lecithin on TMAO production and gut microbiota in general be explored.

1804- NarG,    Beneficial effects of citrus flavanones naringin and naringenin and their food sources on lipid metabolism: An update on bioavailability, pharmacokinetics, and mechanisms
- Review, NA, NA
GutMicro↝, interplays between the flavanones and gut microbiota.
BioAv↝, Gut microbiota plays an important role in the absorption and metabolism of naringenin and naringin

4646- OLEC,    Oleocanthal as a Multifunctional Anti-Cancer Agent: Mechanistic Insights, Advanced Delivery Strategies, and Synergies for Precision Oncology
- Review, Var, NA
BioAv↓, We provide an in-depth analysis of OC’s poor bioavailability
*Inflam↓, well-characterized anti-inflammatory and antioxidant effects
*antiOx↓,
cMET↓, inhibition of key oncogenic signaling pathways (c-MET/STAT3, PAR-2/TNF-α, COX-2/mPGES-1)
STAT3↓,
TNF-α↓,
COX2↓,
EMT↓, the suppression of epithelial-to-mesenchymal transition (EMT), angiogenesis, and metabolic reprogramming
angioG↓,
*GutMicro↝, OC’s bidirectional interaction with gut microbiota
eff↑, OC’s significant potential in combination therapies, detailing its synergistic interactions with standard treatments (e.g., PARP inhibitors, taxanes, FLT3 inhibitors)

4866- ProBio,    Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis
- in-vivo, AD, NA
*memory↑, We found impairments in behaviours reliant on adult hippocampal neurogenesis, an essential process for certain memory functions and mood, resulting from Alzheimer’s patient transplants.
*other↝, Notably, the severity of impairments correlated with clinical cognitive scores in donor patients.
*GutMicro↝, Our findings reveal for the first time, that Alzheimer’s symptoms can be transferred to a healthy young organism via the gut microbiota, confirming a causal role of gut microbiota in Alzheimer’s disease
*GutMicro↝, Alterations in circulatory system and gut microbiota are associated with cognitive status in Alzheimer’s patients
*GutMicro↝, Alzheimer’s patients had a higher abundance of Bacteroidetes (Fig. 1C) reported to comprise many pro-inflammatory species,53 and a lower abundance of the phyla Firmicutes and Verruocomicrobiota, reported to produce beneficial metabolites.

1458- SFN,    Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
- Review, Bladder, NA
HDAC↓, SFN’s role as a natural HDAC-inhibitor is highly relevant
eff↓, SFN exerts stronger anti-proliferative effects on bladder cancer cell lines under hypoxia, compared to normoxic conditions
TumW↓, mice, SFN (52 mg/kg body weight) for 2 weeks reduced tumor weight by 42%
TumW↓, In another study a 63% inhibition was noted when tumor bearing mice were treated with SFN (12 mg/kg body weight) for 5 weeks
angioG↓,
*toxicity↓, In both investigations, the administration of SFN did not evoke apparent toxicity
GutMicro↝, SFN may protect against chemical-induced bladder cancer by normalizing the composition of gut microbiota and repairing pathophysiological destruction of the gut barrier,
AntiCan↑, A prospective study involving nearly 50,000 men indicated that high cruciferous vegetable consumption may reduce bladder cancer risk
ROS↑, Evidence shows that SFN upregulates the ROS level in T24 bladder cancer cells to induce apoptosis
MMP↓,
Cyt‑c↑,
Bax:Bcl2↑,
Casp3↑,
Casp9↑,
Casp8∅,
cl‑PARP↑,
TRAIL↑, ROS generation promotes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity
DR5↑,
eff↓, Blockade of ROS generation inhibited apoptotic activity and prevented Nrf2 activation in cells treated with SFN, pointing to a direct effect of ROS on apoptosis
NRF2↑, SFN potently inhibits carcinogenesis via activation of the Nrf2 pathway
ER Stress↑, endoplasmic reticulum stress evoked by SFN
COX2↓, downregulates COX-2 in T24 cells
EGFR↓, downregulation of both the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2/neu
HER2/EBBR2↓,
ChemoSen↑, gemcitabine/cisplatin and SFN triggered pathway alterations in bladder cancer may open new therapeutic strategies, including a combined treatment regimen to cause additive effects.
NF-kB↓,
TumCCA?, cell cycle at the G2/M phase
p‑Akt↓,
p‑mTOR↓,
p70S6↓,
p19↑, p19 and p21, are elevated under SFN
P21↑,
CD44↓, CD44s expression correlates with induced intracellular levels of ROS in bladder cancer cells variants v3–v7 on bladder cancer cells following SFN exposure
CSCs↓, CD44 is not only involved in cytoskeletal changes and cellular motility but also serves as a cancer stem cell (CSC) marker

3647- SIL,    Silymarin Modulates Microbiota in the Gut to Improve the Health of Sow from Late Gestation to Lactation
- in-vivo, NA, NA
*IL1β↓, dietary silymarin supplementation decreased the level of pro-inflammatory cytokine IL-1β (p < 0.05) on the 18th day of lactation in the blood of the sows.
*GutMicro↝, Dietary silymarin supplementation reduced the gut bacterial community and the richness of the gut microbial community
*Inflam↓, silymarin can reduce the sow inflammatory response, improve mammary gland health, and thus improve lactation performance.

5806- Sper,    Spermidine – an old molecule with a new age-defying immune function
GutMicro↝, Spermidine can be produced by co-metabolism of host-microbiota, as certain bacterial species generate putrescine which colonic epithelial cells can utilize as the source for spermidine production.
GutMicro↝, The reduction of spermidine by aging can be a reflection of the loss of microbial diversity in the gut.

5335- TFdiG,    Microbial Metabolism of Theaflavin-3,3′-digallate and Its Gut Microbiota Composition Modulatory Effects
- in-vivo, Nor, NA
BioAv↓, Theaflavin-3,3′-digallate (TFDG), a bioactive black tea phenolic, is poorly absorbed in the small intestine, and it has been suggested that gut microbiota metabolism plays a crucial role in its bioactivities.
GutMicro↝, including growth-promoting effects on Bacteroides, Faecalibacterium, Parabacteroides, and Bifidobacterium, and inhibitory effects on Prevotella and Fusobacterium.
GutMicro↑, green or black tea extracts could alter the composition and metabolic activities of gut microbiota toward a healthier profile
GutMicro↑, consumption of green or black tea with a standardized phenolic content results in similar gut microbiota modulatory effects, including the growth-promoting effects on Lachnospiraceae and Akkermansia, and inhibitory effects on Clostridium leptum.(20)


Showing Research Papers: 1 to 13 of 13

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 13

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NRF2↑, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,   Bax:Bcl2↑, 1,   Casp3↑, 1,   Casp8∅, 1,   Casp9↑, 1,   Cyt‑c↑, 2,   DR5↑, 1,   TRAIL↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,   p70S6↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 2,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

p19↑, 1,   P21↑, 1,   TumCCA?, 1,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   cMET↓, 1,   CSCs↓, 1,   EMT↓, 1,   HDAC↓, 1,   p‑mTOR↓, 1,   STAT3↓, 1,  

Migration ⓘ

MMP9↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   EGFR↓, 1,   EPR↝, 1,   Hif1a↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL1↑, 1,   IL8↑, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↝, 1,   ChemoSen↑, 1,   eff↓, 2,   eff↑, 4,   RadioS↑, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   GutMicro↑, 2,   GutMicro↝, 8,   HER2/EBBR2↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   TumW↓, 2,  
Total Targets: 49

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

TMAO↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 1,   HDL∅, 1,  

Core Metabolism/Glycolysis ⓘ

LDL↓, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   Inflam↓, 2,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,  

Drug Metabolism & Resistance ⓘ

BioEnh↑, 2,   Dose↝, 1,  

Clinical Biomarkers ⓘ

GutMicro↝, 8,  

Functional Outcomes ⓘ

memory↑, 1,   Obesity↓, 1,   toxicity↓, 1,  
Total Targets: 15

Scientific Paper Hit Count for: GutMicro, Gut Microbiota
3 Silver-NanoParticles
1 Choline
1 Curcumin
1 Lecithin
1 Naringin
1 Oleocanthal
1 probiotics
1 Sulforaphane (mainly Broccoli)
1 Silymarin (Milk Thistle) silibinin
1 Spermidine
1 Aflavin-3,3′-digallate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:350  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

Home Page