CDK1 Cancer Research Results

CDK1, Cyclin-dependent kinase 1: Click to Expand ⟱
Source:
Type:
CDK1, (Cyclin-dependent kinase 1) same as p34 (cdc2) kinase activity
Mitotic Gatekeeper, Essential Cell-Cycle Engine, and Therapeutic Vulnerability
Cell cycle control to gene expression regulation and apoptosis, CDK1 is intimately involved in many cellular events that are vital for cell survival.
CDK1 is a significant biomarker in various cancers, with its overexpression often correlating with aggressive tumor characteristics and poor prognosis. Targeting CDK1 may offer therapeutic potential, especially in cancers where its expression is linked to unfavorable outcomes.
Scientific Papers found: Click to Expand⟱
6976- Form,    Study on the Mechanism of Formononetin Against Hepatocellular Carcinoma: Regulating Metabolic Pathways of Ferroptosis and Cell Cycle
- vitro+vivo, HCC, HepG2
ROS↑, results showed that FM induces oxidative DNA damage through ROS generation and triggers G2/M phase cell cycle arrest via the Chk1/Cdc25C/CDK1/CCNB1 signaling pathway.
DNAdam↑,
TumCCA↑,
CHK1↝,
CDC25↝,
CDK1↝,
CycB/CCNB1↝,
GSH↓, FM limited the synthesis of glutathione, promoted lipid peroxidation, and facilitated the generation of divalent iron.
lipid-P↑,
Ferroptosis↑, FM induces ferroptosis by inhibiting the p53/xCT/GPX4 signaling pathway.
xCT↓,
P53↓,
GPx4↓,
other↝, FM could induce DNA damage leading to cell cycle arrest and may also induce ferroptosis by regulating glutathione metabolism, thereby intervening in the occurrence and development of HCC
TumCP↓, FM Inhibits the Proliferation of HepG2 Cells
γH2AX↑, results revealed a significant down-expression of H2A.X and an up-expression of γ-H2A.X,
TumCG↓, FM Inhibits Tumor Growth In Vivo
Ki-67↓, FM could downregulate the expression of proliferation markers Ki67 and PCNA, as well as the ferroptosis marker GPX4
PCNA↓,
MMP↓, FM could induce the accumulation of ROS and a decrease in MMP in HepG2 cells in a dose-dependent manner


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   lipid-P↑, 1,   ROS↑, 1,   xCT↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↝, 1,   MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CHK1↝, 1,   DNAdam↑, 1,   P53↓, 1,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↝, 1,   CycB/CCNB1↝, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,   TumCP↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CDK1, Cyclin-dependent kinase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:382  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

Home Page