GR Cancer Research Results

GR, glucocorticoid receptors: Click to Expand ⟱
Source:
Type:
Glucocorticoid receptors (GR), also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1), are a type of steroid hormone receptor that mediates the effects of glucocorticoids, which are steroid hormones involved in various physiological processes, including metabolism, immune response, and stress response.
In certain cancer subtypes such as gynaecological cancers (endometrial and ovarian) and early stage, untreated triple negative breast cancers, high GR expression is linked with cancer progression and therefore a poorer patient prognosis.

Glucocorticoid receptors play a significant role in various cancers, and their expression can have complex prognostic implications. In some cancer types, high GR expression is associated with better outcomes, while in others, it may correlate with aggressive disease and treatment resistance. The relationship between glucocorticoid receptor expression and cancer prognosis can vary depending on the specific cancer type, stage, and other molecular factors.
Scientific Papers found: Click to Expand⟱
1709- Lyco,    Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation
- in-vitro, Nor, JB6
*antiOx↑, Lycopene stimulated the activation of antioxidant enzymes and the translocation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) that predominantly maintained intracellular redox equilibrium
*NRF2↑, Lycopene activated the Nrf2 pathway in the presence of carcinogens in vivo and in vitro
*GSH/GSSG↓, Lycopene also rebalanced the GSH/GSSG ratio, partly representing the cellular redox condition commendably
*Catalase↝, catalase (CAT), glutathione reductase (GR), superoxide dismutase (SOD), and glutathione peroxidase (GPx), lower activities of these enzymes were reversed by this compound
*GR↝,
*SOD↝,
*GPx↝,
*GSH↑, mRNA levels of GSH and these antioxidant substances were also up-regulated significantly by lycopene pretreatment
*Keap1↓, Lycopene induced activation of Nrf2 by reducing Keap1 protein
*p62↑, lycopene induced p62 binding to Keap1, so Keap1 degradation was mediated by p62

1310- UA,    Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells
- in-vitro, BC, MCF-7
GR↝,
AP-1↝,
cl‑PARP↑,
Bcl-2↓,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Bcl-2↓, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Migration ⓘ

AP-1↝, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↝, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↝, 1,   GPx↝, 1,   GSH↑, 1,   GSH/GSSG↓, 1,   Keap1↓, 1,   NRF2↑, 1,   SOD↝, 1,  

Autophagy & Lysosomes ⓘ

p62↑, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↝, 1,  
Total Targets: 10

Scientific Paper Hit Count for: GR, glucocorticoid receptors
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:390  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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