CAFs/TAFs Cancer Research Results

CAFs/TAFs, cancer/tumor-associated fibroblast: Click to Expand ⟱

Source:

Type:

Also known as tumour-associated fibroblast TAF
A cell type within the tumor microenvironment that promotes tumorigenic features by initiating the remodelling of the extracellular matrix or by secreting cytokines. CAFs are a complex and abundant cell type within the tumour microenvironment.
Fibroblasts are the most abundant cells in the tumor microenvironment, also called tumor-associated fibroblasts (TAFs). They are known to secrete a variety of soluble factors, such as metalloproteinases (MMPs), enzymes that are related to changes in the extracellular matrix, promoting tumor invasion.

Scientific Papers found: Click to Expand⟱

970-

MET,

Metformin suppresses HIF-1α expression in cancer-associated fibroblasts to prevent tumor-stromal cross talk in breast cancer

CAFs/TAFs↝, p‑AMPK↑, PHDs↑, Hif1a↓, TumCI↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

p‑AMPK↑, 1,

Migration ⓘ

CAFs/TAFs↝, 1, TumCI↓, 1,

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1, PHDs↑, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: CAFs/TAFs, cancer/tumor-associated fibroblast

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells