cognitive Cancer Research Results
cognitive, cognitive: Click to Expand ⟱
Scientific Papers found: Click to Expand⟱
*Risk↑, Each 1-SD increase in baseline p-tau217 level was associated with an increased risk of progression to cognitive impairment
*cognitive↝, Elevated p-tau217 was also associated with faster cognitive decline based on change in latent PACC score
*other↝, In aging and AD, the brain's 5-HT system undergoes structural and functional changes that contribute to cognitive decline.
*cognitive↝, Theoretically, targeted therapies aimed at restoring the brain's 5-HT projection network or functions could potentially have cognitive-enhancing effects in AD. However, preclinical studies have shown inconsistent effects
*cognitive↝, Early studies suggested a beneficial effect of ALC on cognition and behaviour in aging subjects. However, later, larger studies have not supported these findings
*Mood↝,
*cognitive↝, Clinical studies are mixed regarding curcumin’s effects on cognitive deficits.
*BioAv↑, Ways to improve curcumin’s bioavailability are required.
*Inflam↓, anti-inflammatory activity can be attributed to the suppression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) enzymes via down-regulation of nuclear factor kappa B (NF-κB)
*COX2/PTGS2↓,
*iNOS↓,
*NF-kB↓,
*TNF-α↓, nhibition of several inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-a) or interleukin (IL) -1, -2, -6, -8, and -12 (
*IL1↓,
*IL2↓,
*IL6↓,
*IL8↓,
*IL12↓,
*ROS↓, Curcumin’s ability to scavenge free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), provides its antioxidant capacity
*RNS↓,
*antiOx↑,
*BBB↑, Multiple studies in rodents and humans have shown that curcumin crosses the blood brain barrier (BBB)
*BioAv↓, drawback is the low bioavailability due to poor solubility, low absorption, rapid metabolism, and rapid excretion
*cognitive↑, The researchers detected a significant cognitive improvement at both doses compared to the untreated group, while a significant dose-response effect was found throughout time with higher doses of curcumin producing greater cognitive improvement
*memory↑, supplementation may improve memory and result in a number of biochemical alternations leading to suppressed tau aggregation
*tau↓,
*eff↑, Combined curcumin and piperine showed superiority, in a dose dependent manner,
*BrainVol↝, Baseline iron, cysteine, and homocysteine were significantly associated with brain atrophy rate.
*cognitive↝, At baseline, iron, copper, aluminum, and silicon were significantly associated with one or more domains of cognition: semantic memory, verbal episodic memory, attention/processing speed, and executive function.
*cognitive↑, These factors showed domain-specific associations with cognition, which were abrogated by B vitamin therapy.
*Dose↝, daily folic acid (0.8 mg)/vitamin B12 (0.5 mg)/vitamin B6 (20 mg)
*other↝, Reducing the rate of brain atrophy is likely to slow the conversion of individuals with MCI to AD
*Hcy/homoC↓, Elevated plasma total Hcy (tHcy) is associated with brain atrophy in healthy elderly [6] and in AD patients [7].
*Risk↓, Silicon (Si) has been shown to prevent gastrointestinal absorption of Al [17]
*BrainVol∅, In contrast, we found no correlations between brain atrophy rate and baseline serum Cu, As, or Al
*BrainVol↑, B vitamin treatment abrogates associations of brain atrophy rate with Fe and Cys
*other↝, Baseline Fe, Cu, Al, and Si predict cognition in the placebo group at the end of study: multiple regression analysis
*cognitive↑, B vitamin treatment abrogates effects of Fe, Si, Al, and Cu on cognition
*cognitive↑, multiple regression analyses that baseline Fe and Si were associated with better performance in several domains of cognition at the end of study
*other↝, serum Fe levels were reduced [12] and serum Cu levels were elevated [11] in AD patients compared to healthy controls.
*Risk↝, In addition to Fe and Cu, Al is also known to accumulate in senile plaques [15] and a high daily intake of Al is associated with increased risk of dementia
*cognitive↝, Since neuropsychological improvements were best documented after 8 and 16 weeks and faded towards the end of the treatment period, it must be concluded that this symptomatic therapy is mainly of short-term benefit and was overcome by the progressive
*Aβ↓, silicates as a therapeutic agent for AD since both model tangles and precipitated beta-pleated sheets of betaA4 can be reversed to soluble forms by silicates.
*cognitive↝, role of silica in drinking water on cognitive function has been however little studied and clear results have not yet emerge.
*cognitive↝, Current evidence of the effect of spermidine on cognitive function shows inconsistent results based on a few studies with low spermidine doses and a small number of participants. (0.9mg to 3.3mg)
*Dose↝, hat a recent pharmacokinetic study suggested that doses less than 15mg are unlikely to exert
any short-term effects.
*cognitive↝, improved cognition only in patients with pre-existing vitamin B12 deficiency (serum vitamin B12 levels <150 ρmol/L or serum homocysteine levels >19.9 μmol/L).
Showing Research Papers: 1 to 9 of 9
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9
Pathway results for Effect on Cancer / Diseased Cells:
Total Targets: 0
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↑, 1, RNS↓, 1, ROS↓, 1,
Cell Death(tgid=5) ⓘ
iNOS↓, 1,
Transcription & Epigenetics(tgid=7) ⓘ
other↝, 4,
Barriers & Transport(tgid=15) ⓘ
BBB↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
COX2/PTGS2↓, 1, IL1↓, 1, IL12↓, 1, IL2↓, 1, IL6↓, 1, IL8↓, 1, Inflam↓, 1, NF-kB↓, 1, TNF-α↓, 1,
Synaptic & Neurotransmission(tgid=18) ⓘ
BrainVol↑, 1, BrainVol↝, 1, BrainVol∅, 1, tau↓, 1,
Protein Aggregation(tgid=19) ⓘ
Aβ↓, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
BioAv↓, 1, BioAv↑, 1, Dose↝, 2, eff↑, 1,
Clinical Biomarkers(tgid=22) ⓘ
Hcy/homoC↓, 1, IL6↓, 1,
Functional Outcomes(tgid=23) ⓘ
cognitive↑, 4, cognitive↝, 9, memory↑, 1, Mood↝, 1, Risk↓, 1, Risk↑, 1, Risk↝, 1,
Total Targets: 33
Scientific Paper Hit Count for: cognitive, cognitive
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:557 State#:% Dir#:4
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