PD-1 Cancer Research Results

PD-1, Programmed Death-1: Click to Expand ⟱
Source:
Type: protein
PD-1 (Programmed Death-1) is a protein that plays a crucial role in the immune system's ability to fight cancer. It is a checkpoint protein that helps regulate the immune response by preventing the immune system from attacking healthy cells.
PD-1 is often exploited by cancer cells to evade the immune system. Cancer cells can produce proteins that bind to PD-1, inhibiting the immune response and allowing the cancer cells to grow and proliferate unchecked.

However, researchers have discovered that blocking the PD-1 pathway can help restore the immune system's ability to fight cancer. This has led to the development of PD-1 inhibitors, a class of cancer therapies that target the PD-1 protein.

PD-1: Upregulated on tumor-infiltrating lymphocytes (TILs), reflecting chronic antigen exposure and an “exhausted” T cell phenotype.
PD-L1 and PD-L2: Frequently overexpressed by many tumor types (e.g., non–small cell lung cancer, melanoma, renal cell carcinoma, head and neck cancers).
Scientific Papers found: Click to Expand⟱
541- Akk,    Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut-Liver-Brain Axes?
- Review, NA, NA
GutMicro↑, PD-1↝, CD8+↑, IL8↑,
542- Akk,  immuno,    Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
CD4+↑, CXCc↑, PD-1↝,
557- ART/DHA,    Artemisinin and Its Derivatives in Cancer Care
- Review, Var, NA
*BioAv↓, *BioAv↑, Apoptosis↑, EGFR↓, CD31↓, Ki-67↓, P53↓, TfR1/CD71↑, P-gp↓, PD-1↝,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Metal & Cofactor Biology ⓘ

TfR1/CD71↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

DNA Damage & Repair ⓘ

P53↓, 1,  

Migration ⓘ

CD31↓, 1,   Ki-67↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   CXCc↑, 1,   IL8↑, 1,   PD-1↝, 3,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   GutMicro↑, 1,   Ki-67↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: PD-1, Programmed Death-1
2 Akkermansia
1 immunotherapy
1 Artemisinin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:709  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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