Risk Cancer Research Results

Risk, Risk: Click to Expand ⟱

Source:

Type:

Risk: by definition reduces risk of disease or cancer.
Down Target direction of risk indicates lower cancer risk.
ChemoPreventive also mean lower cancer risk. But for Chemopreventive an up arrow indicates more preventive.

Cancer Risk Impact Score (CRIS)
CRIS scale:
–5 = very strong risk reduction
–4 = strong risk reduction
–3 = moderate risk reduction
–2 = modest risk reduction
–1 = weak / context-dependent
0 = neutral


CRIS  Exposure / Compound  Evidence  Cancers  Notes


-5  Exercise (overall)
VStrong Hum  BC, CRC, Endo, PCa, Liv
↓insulin/IGF-1, ↓inflammation, ↑immune surveillance, ↓hormones



-5  Aerobic + resistance  VStrong Hum  Broad inc + mort
Best overall exercise synergy



-4  Aerobic exercise (mod–vig)  VStrong Hum  BC, CRC, Endo
Dose–response; ↓visceral fat



-4  Resistance training (alone)  Strong Hum  BC, CRC
↑insulin sensitivity; ↑lean mass



-3  High-intensity interval training  Mod–Strong Hum  BC, CRC
↑AMPK; ↑mitochondrial function; adherence matters



-2  NEAT / low-intensity activity  Moderate Hum  CRC
↓sedentary harm



-5  Cruciferous vegetable pattern  Strong Hum  Lung, CRC, BC, PCa
↑NRF2, ↓CYP1; ITC synergy



-5  Sunlight exposure (physiologic)  Strong Hum  CRC, BC, PCa
↑circadian alignment, ↑immune effects beyond vitamin D



-4  Fasting (metabolic pattern)
Strong Mech + Hum  BC, CRC, PCa 
↓IGF-1, ↓mTOR, ↑autophagy



-4  Curcumin
Hum + Pre  GI, BC, PCa
↓NF-κB, ↓STAT3



-4  Sulforaphane
Hum + Pre  Lung, CRC, BC
↑NRF2, ↓HDAC



-4  PEITC
Hum + Pre  Lung, CRC, PCa
↓CYP1A2, ↑apoptosis



-4  EGCG (tea matrix)
Strong Hum  GI, PCa, BC
↓angiogenesis; tea matrix superior to extract



-4  Lycopene
Strong Hum  PCa
↓oxidative DNA damage



-4  Apigenin
Pre + Diet Hum  BC, PCa, CRC 
↓PI3K-AKT, ↑p53



-4  Luteolin
Pre + Diet Hum  Lung, CRC, BC 
↓STAT3, ↓EMT



-4  Kaempferol
Diet Hum  Ov, Panc, Lung
↓VEGF, ↑apoptosis



-4  Fisetin
Pre + Early Hum  CRC, PCa, Mel
↓mTOR; senolytic activity



-4  Ellagic acid → Urolithin A
Hum (microbiome)  CRC, PCa, BC
↑mitophagy, ↓ER/AR signaling



-3  Omega-3 (EPA/DHA)
Strong Hum  CRC, BC
↓inflammation, ↓COX-2



-3  Vitamin D3 (supp)
Obs + RCT  CRC, BC
U-shaped response; ↓proliferation



-3  Garlic (allicin)
Mod Hum  GI
↓inflammation, ↓H. pylori



-3  Mushroom beta-glucans
Hum adjunct  GI, BC
↑NK cells, ↑immune surveillance



-3  Melatonin
Hum + Mech  BC, PCa
↓estrogen signaling, ↑circadian regulation



-3  Coffee (whole)
Strong Hum  Liv, Endo
↓fibrosis, ↓inflammation



-2  Quercetin
Limited Hum  Lung, CRC
Senolytic; ↓PI3K signaling



-2  Resveratrol
Limited Hum  CRC, BC
↓NF-κB; low bioavailability



-2  I3C / DIM
Mod Hum  BC, Cerv
↑2-OH estrogen, ↓ER signaling



-2  Thymoquinone
Early Hum  BC, CRC
↑apoptosis, ↓NF-κB



-2  Beta-carotene (food)
Hum  Lung
Antioxidant only in whole-food context



-1  Vitamin K2 (MK-4/7)
Limited Hum  Liv, PCa
↓proliferation, ↑differentiation



-1  Boron
Obs  PCa, Lung
↓inflammation; hormone modulation



0  Vitamin C (oral)
Strong Hum  —
Neutral overall effect



0  Genistein (soy)
Strong Hum  BC, PCa
Timing-dependent effects



0  Selenium (diet)
Mixed Hum  PCa
Narrow therapeutic window



0  Capsaicin
Mixed  Gastric
Dose-dependent effects



+2  Vitamin E (alpha only)
Strong RCT  PCa
Increased risk signal



+2  Green tea extract (high-dose)
Case reports  Liv
Hepatotoxicity reported



+4  Beta-carotene (supplement)
Strong RCT  Lung (smokers)
Increased lung cancer risk in smokers



+5  Alcohol (ethanol)
Strong Hum  BC, Liv, Eso
Linear increase in cancer risk




Evidence
Hum        human data
VStrong    very strong
Strong     strong
Mod        moderate
Obs        observational
Pre        preclinical
RCT        randomized controlled trial
Mech       mechanistic
Adjunct    adjunct clinical use

Scientific Papers found: Click to Expand⟱

5399-

ASA,

Effect of Aspirin on Cancer Incidence and Mortality in Older Adults

Trial,

Nor,

19 114 Australian and US community-dwelling participants aged 70 years and older

Risk↝, aspirin was associated with an increased risk of incident cancer that had metastasized
Risk↑, These findings suggest that in older persons, aspirin may accelerate the progression of cancer and, thus, suggest caution with its use in this age group.
Risk∅, There was no association of aspirin with the overall incidence of solid tumors (HR = 1.05, 95% CI = 0.95 to 1.15) or with the incidence of cancers that were diagnosed at stages 1, 2, or 3.
Risk↑, By contrast, aspirin was associated with an increase in the incidence of cancers presenting at stage 4 (HR = 1.22, 95% CI = 1.02 to 1.45).
other↝, Prostate, colorectal, breast, melanoma, and lung were the most common incident cancers, accounting for 80% of all solid tumor cancers.

5930-

Catechins,

Randomized, Placebo-Controlled Trial of Green Tea Catechins for Prostate Cancer Prevention

Trial,

Pca,

 400 mg (–)-epigallocatechin-3-gallate (EGCG) per day

PSA↓, A decrease in serum prostate specific antigen (PSA) was observed on the PolyE arm
other↑, A significant increase in plasma EGCG concentration was achieved in the treatment arm at 6 and 12 months
Risk↝, was well tolerated but did not reduce the likelihood of a subsequent PCa diagnosis in men with baseline HGPIN or ASAP.

1623-

FA,

Folic acid: friend or foe in cancer therapy

Review,

Var,

Risk↝, conflicting studies regarding the relationship between folic acid and cancer risk.

2141-

Se,

Selenium and cancer risk: Wide-angled Mendelian randomization analysis

Review,

NA,

Dose↝, Nonetheless, a nutrition survey in US people indicated that a trivial proportion of the population had serum levels of selenium >170 ng/mL
Risk↝, Evidence on the association between selenium and cancer risk is inconclusive

2142-

Se,

A U-shaped association between selenium intake and cancer risk

Review,

NA,

*Risk↝, We observed a U-shaped association between selenium intake and cancer risk.
Dose↝, A safe intake ranged from 110.8 to 124.4 µg/day (mean 117.8 µg/day).
*Risk↓, individuals with the lowest intake (i.e., 27.8–77.2 µg/day) were associated with an increased risk of cancer (ie higher levels means lower risk)

4496-

Se,

Selenium status and survival from colorectal cancer in the European prospective investigation of cancer and nutrition

Analysis,

CRC,

Risk↝, Higher levels of Se showed non-significant inverse associations with reduction in both CRC and overall mortality
OS↑, We found no major association of Se status markers with survival after CRC diagnosis, but an association of SELENOP with overall mortality.

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:

Functional Outcomes ⓘ

OS↑, 1, Risk↑, 2, Risk↝, 5, Risk∅, 1,
Total Targets: 9

Pathway results for Effect on Normal Cells:

Functional Outcomes ⓘ

Risk↓, 1, Risk↝, 1,
Total Targets: 2

Scientific Paper Hit Count for: Risk, Risk

3 Selenium
1 Aspirin -acetylsalicylic acid
1 Catechins
1 Folic Acid, Vit B9

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:785  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

Risk Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Transcription & Epigenetics ⓘ

Immune & Inflammatory Signaling ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Pathway results for Effect on Normal Cells:

Functional Outcomes ⓘ

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