SVCT-2 Cancer Research Results

SVCT-2, Sodium-dependent Vitamin C Transporter 2: Click to Expand ⟱
Source:
Type:
SVCT-2 is a protein that plays a role in the transport of vitamin C (ascorbic acid) into cells.
SVCT-2 is expressed in: 70% breast, 60% lung, 80% CRC, 50% Prostate, 70% ovarian, 60% Pancreatic, 50% liver, 60% stomach, 50% esophageal, 60% Head and Neck, 50% Melanoma, 70% GBM, 60% Medulloblastoma.
SVCT-2 was involved in the transport of vitamin C into lung cancer cells and that its inhibition reduced cancer cell growth and survival.
Scientific Papers found: Click to Expand⟱
628- VitC,  Mg,    Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation
- in-vivo, Colon, CT26 - in-vitro, NA, MCF-7 - in-vitro, NA, SkBr3
AntiCan↑, combined vit c and Mg
SVCT-2↝, Cancer cells that showed high SVCT-2 expression levels were more sensitive to AA treatment (SVCT-2 expression was not changed)
TumCD↑, MgSO4 and MgCl2 significantly increased the cell deaths caused by vitamin C treatment
ROS↑,
P21↑,
proCasp3↑,
TumVol↓, cotreating with vitamin C and magnesium ions inhibited tumor growth more effectively than treating with only vitamin C (mouse)
DNAdam↑,
NAD↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

NAD↓, 1,  

Cell Death ⓘ

proCasp3↑, 1,   TumCD↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Barriers & Transport ⓘ

SVCT-2↝, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   TumVol↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SVCT-2, Sodium-dependent Vitamin C Transporter 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:814  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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