IronCh Cancer Research Results

IronCh, Iron Chelator: Click to Expand ⟱
Source:
Type:
Iron Chelator
Scientific Papers found: Click to Expand⟱
7848- ISQ,    Review of anticancer mechanisms of isoquercitin
- Review, Var, NA
BioAv↑, This compound presents similar therapeutic profiles to quercetin but with superior bioavailability, resulting in increased efficacy compared to the aglycone form.
eff↑,
*antiOx↓, pharmacological effects including antioxidant, antiproliferative, anti-inflammatory, anti-hypertensive, and anti-diabetic.
TumCP↓,
*Inflam↓,
*AntiDiabetic↑,
lipid-P↓, The protective effects of IQ in cancer may be due to actions on lipid peroxidation.
*toxicity↓, Flavonoids are a group of polyphenolic compounds and as a part of the human diet, they have very low toxicity in addition to various beneficial health effects
*Half-Life↝, Human "Juice mix" Quercitin - 216 ± 96 mins
*Half-Life↑, Human Shallot flesh Isoquercitin 15 13980 ± 30
*XO↝, IQ exerts antioxidative effects by inhibiting lipid peroxidation via interference with enzyme activity (xanthine oxidase), chelation of redox-active metals, increased absorption of vitamin C, and direct scavenging of ROS
*IronCh↝,
*VitC↑,
*ROS↓,
β-catenin/ZEB1↓, IQ for example, acts directly by inhibiting the nuclear translocation of β-catenin protein and exhibits significant anti-proliferative effects on glioblastoma cells
Casp3↑, IQ activated caspase-3, 8, and 9 and reduced the mitochondrial membrane potential.
Casp8↑,
Casp9↑,
MMP↓,
p‑ERK↓, IQ inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) and promoted the phosphorylation of c-Jun N-terminal kinase (JuNK).
p‑cJun↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

lipid-P↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cJun↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   eff↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   ROS↓, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Half-Life↑, 1,   Half-Life↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   toxicity↓, 1,  
Total Targets: 10

Scientific Paper Hit Count for: IronCh, Iron Chelator
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:835  State#:%  Dir#:4
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