ER-α36 Cancer Research Results

ER-α36, estrogen receptor alpha (ERα) protein variant: Click to Expand ⟱
Source:
Type:
ER-α36 is a variant of the estrogen receptor alpha (ERα) protein. It is a truncated form of the full-length ERα protein.
ER-α36 is overexpressed in certain types of breast cancer, including triple-negative breast cancer (TNBC) and tamoxifen-resistant breast cancer. ER-α36 has been found to promote cell proliferation, migration, and invasion in breast cancer cells, contributing to tumor progression and metastasis. The expression of ERα is a significant factor in the prognosis of various cancers, particularly in breast and endometrial cancers, where it is a key target for therapy. The relationship between ERα expression and prognosis can vary widely among different cancer types, and ongoing research is essential to fully understand its role in cancer biology and treatment response.
Scientific Papers found: Click to Expand⟱
7733- isoFl,    Soy-derived isoflavones as chemo-preventive agents targeting multiple signalling pathways for cancer prevention and therapy
- Review, Var, NA
chemoPv↑, The chemopreventive and chemotherapeutic properties of soy and soy-derived compounds, especially isoflavones, have been extensively studied in recent years.
HOTAIR↓, soy-derived isoflavones act as, among other things, potent modulators of HOX transcript antisense RNA (HOTAIR)/SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1),
VEGF↓, vascular endothelial growth factor (VEGF)/C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor type 4 (CXCR4),
CXCL12↓,
CXCR4↓,
ER-α36↝, 17-β-oestradiol (E2)/oestrogen receptor-α (ERα)/neuroglobin (NGB) and sonic hedgehog signalling pathways, epigenetic modulatory agents (i.a. miR-155, miR-34a and miR-10a-5p)
Shh↓,
miR-155↝,
miR-34a↝,
miR-10a-5p↝,
CSCs↓, and cancer stem cells and epithelial-to-mesenchymal transition inhibitors.
EMT↓,

4840- Uro,    Urolithin A: A promising selective estrogen receptor modulator and 27-hydroxycholesterol attenuator in breast cancer
- vitro+vivo, BC, NA
MMP↓, findings suggested that UA had an antiproliferative capacity and attenuated the proliferative effects of 27-HC, resulting in subsequent loss of membrane potential and apoptosis in breast cancer cells.
TumCP↓,
Apoptosis↑,
tumCV↓, Our in vivo hollow fiber assay results showed a loss of cell viability in breast cancer cells upon UA consumption, as well as a reduction in 27-HC-induced proliferative activity.
ER-α36↝, UA has the potential to act as a potent estrogen receptor alpha (ERα) modulator and 27-HC antagonist.
*toxicity↓, UA is safe to consume and is very well tolerated


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

HOTAIR↓, 1,   miR-10a-5p↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   EMT↓, 1,   miR-34a↝, 1,   Shh↓, 1,  

Migration(tgid=13) ⓘ

CXCL12↓, 1,   ER-α36↝, 2,   miR-155↝, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CXCR4↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: ER-α36, estrogen receptor alpha (ERα) protein variant
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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