SLC12A5 Cancer Research Results

SLC12A5, SLC12A5: Click to Expand ⟱
Source:
Type:
SLC12A5 is a gene that encodes a protein called KCC2, which is a potassium-chloride cotransporter. This protein plays a crucial role in maintaining the balance of potassium and chloride ions in cells, particularly in neurons.
SLC12A5 has been found to be overexpressed in glioblastoma, breast, lung, CRC.
SLC12A5 has been found to promote cell proliferation in cancer cells.
Scientific Papers found: Click to Expand⟱
5732- Buty,    GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon
- Study, CRC, NA
HCAR2↑, other↓, Apoptosis↑, HDAC↓, Bcl-2↓, Bcl-xL↓, cycD1/CCND1↓, DR5↑, NF-kB↓, GutMicro↑, SLC12A5↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   DR5↑, 1,  

Kinase & Signal Transduction ⓘ

HCAR2↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,  

Barriers & Transport ⓘ

SLC12A5↝, 1,  

Immune & Inflammatory Signaling ⓘ

HCAR2↑, 1,   NF-kB↓, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SLC12A5, SLC12A5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:875  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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