SLC12A5 Cancer Research Results

SLC12A5, SLC12A5: Click to Expand ⟱
Source:
Type:
SLC12A5 is a gene that encodes a protein called KCC2, which is a potassium-chloride cotransporter. This protein plays a crucial role in maintaining the balance of potassium and chloride ions in cells, particularly in neurons.
SLC12A5 has been found to be overexpressed in glioblastoma, breast, lung, CRC.
SLC12A5 has been found to promote cell proliferation in cancer cells.
Scientific Papers found: Click to Expand⟱
5732- Buty,    GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon
- Study, CRC, NA
HCAR2↑, Millimolar concentrations of butyrate are needed to activate the receptor.
other↓, The expression of GPR109A is silenced in colon cancer in humans, in a mouse model of intestinal/colon cancer, and in colon cancer cell lines.
Apoptosis↑, Re-expression of GPR109A in colon cancer cells induces apoptosis, but only in the presence of its ligands butyrate and nicotinate.
HDAC↓, Butyrate is an inhibitor of histone deacetylases, but apoptosis induced by activation of GPR109A with its ligands in colon cancer cells does not involve inhibition of histone deacetylation.
Bcl-2↓, primary changes in this apoptotic process include downregulation of Bcl-2, Bcl-xL, and cyclin D1, and upregulation of death receptor pathway.
Bcl-xL↓,
cycD1/CCND1↓,
DR5↑,
NF-kB↓, In addition, GPR109A/butyrate suppresses NF-κB activation in normal and cancer colon cell lines as well as in normal mouse colon.
GutMicro↑, Gut bacteria play a critical role in the prevention of colon cancer and inflammatory bowel disease
SLC12A5↝, We have shown previously that butyrate induces apoptosis in colon cancer cell lines if SLC5A8, a butyrate transporter, is expressed in these cells and that the process is associated with inhibition of HDACs


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   DR5↑, 1,  

Kinase & Signal Transduction ⓘ

HCAR2↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,  

Barriers & Transport ⓘ

SLC12A5↝, 1,  

Immune & Inflammatory Signaling ⓘ

HCAR2↑, 1,   NF-kB↓, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SLC12A5, SLC12A5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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