eff Cancer Research Results

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Scientific Papers found: Click to Expand⟱
5269- 3BP,    The anti-metabolite KAT/3BP has in vitro and in vivo anti-tumor activity in lymphoma models.
- in-vitro, HCC, NA
toxicity↑, eff↝, eff↑, Glycolysis↓, HK2↓, AIF↑, Apoptosis↑, NK cell↑, toxicity↑, toxicity↓, Dose↝, AntiTum↑,
3452- 5-ALA,    5-ALA Is a Potent Lactate Dehydrogenase Inhibitor but Not a Substrate: Implications for Cell Glycolysis and New Avenues in 5-ALA-Mediated Anticancer Action
- in-vitro, GBM, T98G - in-vitro, GBM, LN-18 - in-vitro, GBM, U87MG
Glycolysis↓, LDH↓, eff↝, ECAR↓,
3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,
5464- AF,    Inhibition of Thioredoxin-Reductase by Auranofin as a Pro-Oxidant Anticancer Strategy for Glioblastoma: In Vitro and In Vivo Studies
- vitro+vivo, GBM, NA
TrxR↓, BioAv↓, ROS↑, eff↝, TET1?, BioAv↑,
5458- AF,    Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer
- in-vitro, NSCLC, NA
TrxR↓, AntiCan↓, GPx4↓, DNAdam↑, toxicity↓, eff↝,
5468- AF,    The gold complex auranofin: new perspectives for cancer therapy
- Review, Var, NA
TrxR↓, ROS↑, eff↑, Apoptosis↑, TumCG↓, TumCP↓, Akt↓, NF-kB↓, DNAdam↑, eff↝, eff↓, PI3K↓, Akt↓, mTOR↓, Hif1a↓, VEGF↓, Casp3↑, CSCs↓, ATP↓, Glycolysis↓, eff↑, eff↑, MMP↓, AIF↑, toxicity↓,
1903- AgNPs,    Novel Silver Complexes Based on Phosphanes and Ester Derivatives of Bis(pyrazol-1-yl)acetate Ligands Targeting TrxR: New Promising Chemotherapeutic Tools Relevant to SCLC Managemen
- in-vitro, Lung, U1285
TrxR↓, eff↝, ROS↑,
4421- AgNPs,    Effect of Biologically Synthesized Silver Nanoparticles on Human Cancer Cells
- in-vitro, Cerv, NA
selectivity↑, eff↝, other↝,
4362- AgNPs,    Enhancing Colorectal Cancer Radiation Therapy Efficacy using Silver Nanoprisms Decorated with Graphene as Radiosensitizers
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vivo, NA, NA
eff↑, TumCG↓, OS↑, RadioS↑, eff↑, ROS↑, DNAdam↑, eff↝,
4554- AgNPs,    Involvement of telomerase activity inhibition and telomere dysfunction in silver nanoparticles anticancer effects
- in-vitro, Cerv, HeLa
Telomerase↓, eff↝,
4553- AgNPs,    Cytotoxicity induced by engineered silver nanocrystallites is dependent on surface coatings and cell types
- in-vitro, Nor, RAW264.7
*Wound Healing↑, *eff↝, *toxicity↝,
4600- AgNPs,    Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model
- in-vivo, Nor, NA
*Half-Life↝, *toxicity↓, *Dose↑, *other↝, *eff↝, *BioAv↓,
5147- AgNPs,    Size dependent anti-invasiveness of silver nanoparticles in lung cancer cells
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, ROS↑, p‑NF-kB↑, selectivity↑, eff↝,
5144- AgNPs,    Differential effects of silver nanoparticles on DNA damage and DNA repair gene expression in Ogg1-deficient and wild type mice
- in-vivo, Nor, NA
*DNAdam↑, *toxicity↝, eff↝,
2836- AgNPs,  Gluc,    Glucose capped silver nanoparticles induce cell cycle arrest in HeLa cells
- in-vitro, Cerv, HeLa
eff↝, TumCCA↑, eff↑, eff↑, ROS↑, GSH↓, SOD↓, lipid-P↑, LDH↑,
2835- AgNPs,  Gluc,    Carbohydrate functionalization of silver nanoparticles modulates cytotoxicity and cellular uptake
- in-vitro, Liver, HepG2
Dose↝, eff↑, ROS↑, eff↝, eff↑, eff↝, eff↑, eff↝,
5324- ALC,    The anti-wasting effects of L-carnitine supplementation on cancer: experimental data and clinical studies
- Review, Var, NA
*cachexia↓, *Apoptosis↓, *Inflam↓, QoL↑, Dose↝, Weight↑, OS↝, fatigue↓, eff↝,
5357- almon,    AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations
- Trial, NSCLC, NA
EGFR↓, eff↝, OS↑,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2584- Api,  Chemo,    The versatility of apigenin: Especially as a chemopreventive agent for cancer
- Review, Var, NA
ChemoSen↑, RadioS↑, eff↝, DR5↑, selectivity↑, angioG↓, selectivity↑, chemoP↑, MAPK↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, GLUT1↓, radioP↑, BioAv↓, chemoPv↑,
3824- Aroma,    Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties
- Human, AD, NA
*cognitive↑, *memory↑, *AChE∅, *Mood↑, *eff↝,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
5379- ART/DHA,    Iron-fueled ferroptosis: a new axis for immunomodulation to overcome cancer drug resistance—from immune microenvironment crosstalk to therapeutic translation
Ferritin↓, Iron↑, Fenton↑, lipid-P↑, ChemoSen↑, ROS↑, eff↝,
2001- Ash,    Withania somnifera: from prevention to treatment of cancer
- Review, Var, NA
toxicity↓, TumW↓, Dose?, eff↝, Ki-67↓, survivin↓, XIAP↓, PERK↑, p‑RSK↑, CHOP↑, DR5↑, Dose↝, BG↓, DNMTs↓,
5362- AV,    Anti-cancer effects of aloe-emodin: a systematic review
- Review, Var, NA
AntiCan↑, eff↝, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumCD↑, MMP↓, ROS↑, Apoptosis↑, CDK1↓, CycB/CCNB1↓, Bcl-2↓, PCNA↓, ATP↓, ER Stress↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, MMP2↓, Ca+2↑, DNAdam↑, Akt↓, PKCδ↓, mTORC2↓, GSH↓, ChemoSen↑,
5574- B-Gluc,    Beta Glucan: Health Benefits in Obesity and Metabolic Syndrome
- Review, Obesity, NA
*BioAv↑, *toxicity↓, *Imm↑, *eff↑, *Risk↓, *Weight↓, *eff↝, *BP↓, *GutMicro↑, *eff↓,
2612- Ba,  MF,    effect_of_a_static_magnetic_field_and_baicalin_or_baicalein_interactions_on_amelanotic_melanoma_cell_cultures_C32">The effect of a static magnetic field and baicalin or baicalein interactions on amelanotic melanoma cell cultures (C32)
- in-vitro, Melanoma, NA
SOD1↑, SOD2↑, GPx1↑, Dose?, eff↝, SOD1↓, SOD2↓, GPx1↓,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1↓, COX2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
5513- bemA,    ACLY inhibition promotes tumour immunity and suppresses liver cancer
- in-vitro, Liver, NA
ACLY↓, AMPK↑, eff↑, other↝, eff↝,
5583- BetA,    Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells
- vitro+vivo, NA, NA
ROS↑, Bcl-2↓, BAX↑, TOP1↝, eff↝, toxicity↓, toxicity↓, selectivity↑,
5687- BJ,    Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways
- vitro+vivo, AML, U937
Apoptosis↑, Casp8↑, TumCCA↑, cl‑PARP↑, eff↝, TumCG↓, necrosis↑, Fas↑, TumCCA↑, selectivity↑,
5475- BM,    The Purified Extract from the Medicinal Plant Bacopa monnieri, Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and Apoptosis
- in-vitro, Colon, HT29 - in-vitro, Colon, SW48 - in-vitro, Colon, SW-620 - in-vitro, CRC, HCT116
AQPs↓, TumCG↓, TumCCA↓, Apoptosis↑, eff↝,
5740- Buty,    A Review of Nutritional Regulation of Intestinal Butyrate Synthesis: Interactions Between Dietary Polysaccharides and Proteins
- Review, RCC, NA
*eff↓, Dose↝, eff↑, HDAC↓, ac‑H3↓, ac‑H4↓, *HCAR2↑, *Inflam↓, *ROS↓, *NRF2↑, *GSH↑, *CLDN1↑, *ZO-1↑, IL1β↓, IL6↓, COX2↓, eff↝, eff↑, other↝,
2399- CA,  EA,    Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation
- Review, Col, NA
eff↝, eff↑, Weight↑,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, eff↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, eff↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, eff↑, eff↑, eff↑,
5778- Calc,  VitD3,    Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies
- Study, CRC, NA
Risk↓, eff↝, Risk↓,
5775- Calc,    Calcium Intake and Risk of Colorectal Cancer in the NIH-AARP Diet and Health Study
- Study, CRC, NA
Risk↓, Dose↓, eff↝,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, BioAv↝, BioAv↑,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
2175- Chemo,  VitB12,  FA,    Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients
- Study, BC, NA
other↓, other↝, homoC↓, eff↝, other↝,
5994- Chit,    Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
- Review, Var, NA
angioG↓, *Imm↑, *antiOx↑, selectivity↑, other↝, toxicity↓, BioAv↑, eff↝, Half-Life↑, MPT↑, MMP9↓, lipid-P↑, EPR↑, NK cell↑, Casp3↑, Casp8↑, TumCCA↑, ROS↑, DDS↑, VEGF↓, TIMP1↑, ChemoSen↑, eff↑,
4767- CoQ10,    Efficacy of Coenzyme Q10 for Improved Tolerability of Cancer Treatments: A Systematic Review
- Review, Var, NA
chemoP↑, cardioP↑, hepatoP↑, eff↝,
2808- CUR,    Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation
- in-vitro, Liver, HUH7
Ferritin↓, IronCh↑, TumAuto↑, Apoptosis↑, eff↝, Dose↝,
1844- dietFMD,    Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment
- Review, NA, NA
Risk↓, AMPK↑, Akt↓, mTOR↓, SIRT1↑, Hif1a↓, NRF2↓, SOD↑, ROS↑, IGF-1↓, p‑Akt↓, PI3K↑, GutMicro↑, OS↑, eff↝, ROS↑, TumCCA↑, *DNArepair↑, DNAdam↑,
1853- dietFMD,    Impact of Fasting on Patients With Cancer: An Integrative Review
- Review, Var, NA
*toxicity∅, QoL∅, eff↑, eff↝, ChemoSideEff↓, TumCG↓, Dose↑, toxicity↝, eff↑, IGF-1↑, *OXPHOS↑, BG↓, Insulin↓, RadioS↑,
2170- dietMet,    Low Protein Intake is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population
- Study, Var, NA
OS↑, eff↝, other↝,
5192- dietMet,    Intermittent methionine restriction reduces IGF‐1 levels and produces similar healthspan benefits to continuous methionine restriction
OS↑, eff↝, IGF-1↓, adiP↑, Leptin↓, Weight↓,
2165- dietP,  SFN,    Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study
- Trial, PC, NA
Dose↝, OS↑, eff↝,
5070- dietSTF,    A review of fasting effects on the response of cancer to chemotherapy
- Review, Var, NA
chemoP↑, ChemoSen↑, *DNArepair↑, *Apoptosis↓, *CD8+↑, UPR↑, eff↝, TumAuto↑,

Showing Research Papers: 1 to 50 of 119
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 119

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 1,   Ferroptosis↑, 1,   GPx1↓, 1,   GPx1↑, 1,   GPx4↓, 2,   GSH↓, 3,   Iron↑, 1,   lipid-P↑, 3,   NRF2↓, 2,   ROS↑, 19,   SOD↓, 2,   SOD↑, 1,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   TrxR↓, 4,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 3,   IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 2,   ATP↓, 3,   CDC2↓, 1,   ETC↓, 1,   Insulin↓, 1,   MEK↓, 1,   MMP↓, 5,   MPT↑, 1,   Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   adiP↑, 1,   AMPK↑, 4,   AMPK↝, 1,   cMyc↓, 1,   ECAR↓, 1,   Glycolysis↓, 4,   HK2↓, 1,   homoC↓, 1,   LDH↓, 1,   LDH↑, 1,   NADPH↓, 1,   NADPH↑, 1,   PIK3CA↓, 1,   p‑S6K↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 8,   p‑Akt↓, 1,   Apoptosis↑, 9,   BAD↑, 1,   BAX↑, 4,   Bax:Bcl2↑, 3,   Bcl-2↓, 3,   Casp↑, 1,   Casp12↑, 1,   Casp3↑, 5,   cl‑Casp3↑, 2,   Casp8↑, 4,   Casp9↑, 4,   cl‑Casp9↑, 1,   CK2↓, 1,   Cyt‑c↑, 4,   DR5↑, 2,   Fas↑, 3,   FasL↑, 2,   Ferroptosis↑, 1,   JNK↑, 2,   MAPK↓, 2,   MAPK↑, 1,   necrosis↑, 1,   p27↑, 2,   p38↑, 1,   p‑RSK↑, 1,   survivin↓, 1,   Telomerase↓, 4,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

ac‑H3↓, 1,   ac‑H4↓, 1,   other↓, 1,   other↝, 7,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   GRP78/BiP↓, 1,   HSP90↓, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

BNIP3↝, 1,   LC3II↑, 2,   p62↓, 2,   TumAuto↑, 4,  

DNA Damage & Repair ⓘ

DNAdam↑, 7,   DNMTs↓, 1,   p16↑, 1,   P53↑, 1,   cl‑PARP↑, 3,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 4,   CDK4↑, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   CycD3↓, 1,   cycE/CCNE↓, 2,   P21↑, 1,   RB1↑, 1,   TumCCA↓, 2,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CSCs↓, 5,   Diff↓, 1,   EMT↓, 4,   ERK↓, 2,   ERK↑, 1,   FOXO3↑, 1,   Gli↓, 1,   Gli1↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   HDAC3↓, 1,   IGF-1↓, 3,   IGF-1↑, 1,   mTOR↓, 4,   mTOR↝, 1,   p‑mTORC1↓, 1,   mTORC2↓, 1,   n-MYC↓, 1,   Nestin↓, 1,   NOTCH↓, 2,   PI3K↓, 5,   PI3K↑, 1,   PTEN↑, 1,   Smo↓, 1,   SOX2↓, 1,   STAT3↓, 4,   p‑STAT3↓, 1,   TOP1↝, 1,   TRPM7↓, 1,   TumCG↓, 5,   Wnt↓, 2,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

Ca+2↑, 3,   E-cadherin↓, 1,   E-cadherin↑, 3,   FAK↓, 1,   Ki-67↓, 1,   MMP2↓, 6,   MMP9↓, 6,   MMPs↓, 1,   PKCδ↓, 1,   TET1?, 1,   TIMP1↑, 1,   TSP-1↑, 1,   TumCI↓, 3,   TumCMig↓, 4,   TumCP↓, 2,   TumMeta↓, 1,   Twist↓, 1,   uPA↓, 3,   Vim↓, 1,   β-catenin/ZEB1↓, 5,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   angioG↑, 1,   EGFR↓, 4,   EPR↑, 1,   Hif1a↓, 6,   VEGF↓, 8,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

AQPs↓, 1,   GLUT1↓, 2,  

Immune & Inflammatory Signaling ⓘ

CCR7↓, 1,   COX2↓, 5,   CXCR4↓, 1,   IL1β↓, 1,   IL6↓, 3,   IL8↓, 2,   Inflam↓, 1,   JAK2↓, 1,   p‑JAK2↓, 1,   MCP1↓, 1,   NF-kB↓, 4,   p‑NF-kB↑, 1,   NK cell↑, 2,   PGE2↓, 3,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,   CDK6↑, 1,   Leptin↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 2,   BioEnh↑, 1,   ChemoSen↑, 11,   DDS↑, 1,   Dose?, 3,   Dose↓, 2,   Dose↑, 2,   Dose↝, 8,   Dose∅, 1,   eff↓, 2,   eff↑, 28,   eff↝, 46,   Half-Life↓, 1,   Half-Life↑, 1,   RadioS↑, 6,   selectivity↑, 8,  

Clinical Biomarkers ⓘ

BG↓, 2,   EGFR↓, 4,   Ferritin↓, 3,   GutMicro↑, 2,   HER2/EBBR2↓, 1,   IL6↓, 3,   Ki-67↓, 1,   LDH↓, 1,   LDH↑, 1,  

Functional Outcomes ⓘ

AntiCan↓, 1,   AntiCan↑, 4,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 3,   chemoPv↑, 2,   ChemoSideEff↓, 1,   fatigue↓, 1,   hepatoP↑, 1,   NDRG1↑, 1,   OS↑, 6,   OS↝, 1,   QoL↑, 1,   QoL∅, 1,   radioP↑, 1,   Risk↓, 4,   toxicity↓, 7,   toxicity↑, 3,   toxicity↝, 1,   TumW↓, 1,   Weight↓, 1,   Weight↑, 2,  
Total Targets: 236

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 3,   GPx↑, 1,   GSH↑, 2,   HDL↑, 1,   MDA↓, 1,   NRF2↑, 1,   OXPHOS↑, 1,   ROS↓, 2,   SOD↑, 1,   VitC↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

adiP↓, 1,   LDL↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↓, 2,   Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   MAPK↓, 1,  

Kinase & Signal Transduction ⓘ

HCAR2↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 3,   other↝, 3,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,   HSPs↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   DNArepair↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 1,  

Migration ⓘ

CLDN1↑, 1,   MMP9↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 1,   CRP↓, 2,   CXCR4↓, 1,   HCAR2↑, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 2,   IL6↓, 1,   Imm↑, 2,   Inflam↓, 6,   PGE2↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE∅, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   Dose↑, 1,   Dose⇅, 1,   eff↓, 5,   eff↑, 1,   eff↝, 6,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,   CRP↓, 2,   GutMicro↑, 2,   IL6↓, 1,  

Functional Outcomes ⓘ

BOLD↑, 1,   cachexia↓, 1,   cardioP↑, 3,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 2,   Mood↑, 1,   neuroP↑, 4,   Risk↓, 4,   toxicity↓, 3,   toxicity↝, 2,   toxicity∅, 1,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 74

Scientific Paper Hit Count for: eff, efficacy
14 Magnetic Fields
11 Silver-NanoParticles
5 Vitamin B12
5 Folic Acid, Vit B9
5 Hydrogen Gas
5 Selenium
4 Phenylbutyrate
4 Thymoquinone
3 Auranofin
3 Apigenin (mainly Parsley)
3 Magnetic Field Rotating
3 Resveratrol
3 Selenite (Sodium)
3 Selenium NanoParticles
3 Shikonin
2 Glucose
2 Chemotherapy
2 Artemisinin
2 Baicalein
2 Berberine
2 Caffeic acid
2 Propolis -bee glue
2 Calcium
2 Vitamin D3
2 diet FMD Fasting Mimicking Diet
2 diet Methionine-Restricted Diet
2 Sulforaphane (mainly Broccoli)
2 Quercetin
2 metronomic chemo
2 Radiotherapy/Radiation
2 Vitamin C (Ascorbic Acid)
1 3-bromopyruvate
1 5-Aminolevulinic acid
1 Anthocyanins
1 Acetyl-l-carnitine
1 almonertinib
1 Aromatherapy
1 Ashwagandha(Withaferin A)
1 Aloe anthraquinones
1 beta-glucans
1 bempedoic acid
1 Betulinic acid
1 Brucea javanica
1 Bacopa monnieri
1 Butyrate
1 Ellagic acid
1 Carvacrol
1 Thymol-Thymus vulgaris
1 Celastrol
1 chitosan
1 Coenzyme Q10
1 Curcumin
1 diet Plant based
1 diet Short Term Fasting
1 Electrical Pulses
1 Exercise
1 Fenbendazole
1 flavonoids
1 Kaempferol
1 MCToil
1 Gold NanoParticles
1 Juglone
1 Methylene blue
1 capecitabine
1 Hyperthermia
1 Moringa oleifera
1 Bicarbonate(Sodium)
1 Dichloroacetate
1 temozolomide
1 Piperlongumine
1 Radio Frequency
1 Rosmarinic acid
1 SonoDynamic Therapy UltraSound
1 Oxygen, Hyperbaric
1 Silymarin (Milk Thistle) silibinin
1 Taurine
1 Tumor Treating Fields
1 Vitamin B6,pyridoxine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:961  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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