CLDN1 Cancer Research Results

CLDN1, claudin-1: Click to Expand ⟱

Source:

Type: gene

The CLDN1 gene (Claudin-1) is a tight junction protein that plays a crucial role in maintaining epithelial barrier function and regulating cell-cell adhesion.

Breast cancer: Elevated in 50% of breast cancer, associated with poor prognosis
Lung cancer: Elevated in 60% of lung cancer tissues, associated with poor prognosis
Colorectal cancer: Elevated in 70%, associated with poor prognosis
Prostate cancer: REDUCED in 40%, and associated with poor prognosis
Ovarian cancer: Elevated in 55%, associated with poor prognosis
Gastric cancer:Elevated in 60%, associated with poor prognosis
Hepatocellular carcinoma:Elevated in 65%, associated with poor prognosis
Pancreatic cancer: Elevated in 75%, associated with poor prognosis

Scientific Papers found: Click to Expand⟱

3129-

VitC,

Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis

in-vivo,

Stroke,

*BBB↑, *MMP9↓, *MMPs↓, *MMP2↓, *CLDN1↝, *ZO-1↝, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Drug Metabolism & Resistance ⓘ

eff↑, 1,
Total Targets: 1

Pathway results for Effect on Normal Cells:

Migration ⓘ

CLDN1↝, 1, MMP2↓, 1, MMP9↓, 1, MMPs↓, 1, ZO-1↝, 1,

Barriers & Transport ⓘ

BBB↑, 1,
Total Targets: 6

Scientific Paper Hit Count for: CLDN1, claudin-1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells