AntiCan Cancer Research Results

AntiCan, Anticancer Effect: Click to Expand ⟱
Source:
Type: general indicator
Anticancer Effect


Scientific Papers found: Click to Expand⟱
1890- MGO,    The Dual-Role of Methylglyoxal in Tumor Progression – Novel Therapeutic Approaches
- Review, Var, NA
AntiCan?, MGO levels are increased in several types of cancer, however the MGO contribution in tumor progression is still debated.
TumCG↓, High MGO levels cause growth arrest in several types of cancer. Conversely, a lower increase in MGO concentrations can promote cancer growth.
GAPDH↓, tumoricidal effect of MGO was attributed to the potent inactivation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
Apoptosis↑, Millimolar concentration of MGO induces apoptosis in various cancer cell types
TumCCA↑, Apoptosis was primary due to the block of cell cycle progression
MAPK↑, activation of mitogen-activated protein kinase (MAPK) family (p-JNK, p-ERK and p-p38 levels)
Bcl-2↓, downregulation of B-cell lymphoma 2 (Bcl-2) and matrix metalloproteinase 9 (MMP-9)
MMP9↓,
eff↑, Metronomic doses of MGO are able to sensitize breast cancer cells to doxorubicin and cisplatin, thus inducing cell death, without any additional deleterious effects


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

GAPDH↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Bcl-2↓, 1,   MAPK↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Migration ⓘ

MMP9↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Functional Outcomes ⓘ

AntiCan?, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: AntiCan, Anticancer Effect
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:813  State#:%  Dir#:5
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