BBB Cancer Research Results

BBB, Blood-Brain Barrier Permeability: Click to Expand ⟱
Source:
Type:
Blood-Brain Barrier(BBB) is a term often used regarding if a product has the ability to cross the BBB.
Scientific Papers found: Click to Expand⟱
4291- EGCG,    Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro
- in-vitro, AD, NA
*tau↓, EGCG, abundant in green tea, has long been known to disaggregate tau and other amyloid fibrils, but EGCG has poor drug-like properties, failing to fully penetrate the brain.
*BBB∅, EGCG itself is a poor therapeutic candidate owing to its polyphenolic molecular structure, which results in unfavorable drug-like properties and restricts brain penetration.

7026- Fuc,    Fucoidan
- Review, AD, NA
*Inflam↓, May reduce immune cell mediated inflammation and oxidative stress, but has very low oral bioavailability.
*ROS↓,
*BioAv↓,
*GutMicro↑, May exert beneficial effects through modulation of the intestine/microbiome
*neuroP↑, Neuroprotective Benefit: Can protect against onset of inflammatory and oxidative damage by mitigating immune cell activation in animal models.
*glucose↝, May help regulate glucose homeostasis, have anti-thrombotic effects, and improve tolerability of chemotherapy, but benefits are limited by poor oral bioavailability.
*AntiThr↑,
*chemoP↑,
*Half-Life↝, Half-life: Varies with preparation (~1-3 hours in rats)
*BBB∅, BBB: Not penetrant
*AntiAge↑, Diets rich in fucoidan associated with increased lifespan and lower cancer incidence.
Risk↑,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Functional Outcomes(tgid=23) ⓘ

Risk↑, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   chemoP↑, 1,   neuroP↑, 1,  
Total Targets: 12

Scientific Paper Hit Count for: BBB, Blood-Brain Barrier Permeability
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1123  State#:%  Dir#:6
  wNotes=on  sortOrder:rid,rpid

 

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