QoL Cancer Research Results

QoL, Quality of Life: Click to Expand ⟱
Source:
Type:
Quality of Life
Scientific Papers found: Click to Expand⟱
1879- DCA,    Long-term stabilization of metastatic melanoma with sodium dichloroacetate
- Case Report, Melanoma, NA
OS↑, DCA therapy, with no concurrent conventional therapy, resulted in regression and stabilization of recurrent metastatic melanoma for over 4 years’ duration, with trivial side effects.
toxicity↓, DCA was noted to have an absence of renal, pulmonary, bone marrow and cardiac toxicity
Dose∅, Active hexose correlated compound or AHCC , dandelion root, curcumin, and astragalus root. Parenteral therapy was also started, which consisted of intravenous vitamin C twice weekly and subcutaneous European mistletoe extract. +vegan diet
Dose∅, DCA 500 mg 3 times per day, which was equivalent to 17 mg/kg per day (manufacturer: Tokyo Chemical Industry, United States) in addition to maintaining the other natural therapies. 2 wk on and 1 wk off
Dose∅, To minimize the occurrence of DCA side effects, 3 additional natural medications were prescribed: Oral acetyl L-carnitine 500 mg 3 times a day, oral benfotiamine 80 mg twice a day and oral R-alpha lipoic acid 150 mg 3 times a day
QoL∅, DCA therapy can be used without reducing quality of life

1853- dietFMD,    Impact of Fasting on Patients With Cancer: An Integrative Review
- Review, Var, NA
*toxicity∅, Data suggest overall good compliance, no malnutrition, minimal side effects. No significant changes were identified to suggest increased harm.
QoL∅, unchanged quality of life (QOL),
eff↑, improved endocrine parameters
eff↝, mixed results for cancer outcomes
ChemoSideEff↓, decreasing chemotherapy-related side effects
TumCG↓, limiting tumor growth
Dose↑, When fasting is used as an adjunct to chemotherapy, a minimum fasting period of at least 48 hours is currently recommended for nutritional interventions in order to achieve a measurable metabolic response at the cellular level
toxicity↝, The increased risk for poor outcomes associated with malnutrition, weight loss, and cachexia poses an obvious safety concern for patients with cancer who participate in calorie-restricted fasting
eff↑, short-term fasting involving water-only or limited daily calorie consumption for less than a week has the potential to achieve positive metabolic changes while avoiding malnutrition and significant weight loss
IGF-1↑, statistically significant decrease in IGF-1 among participants compliant with fasting compared with regular diet during the middle of therapy
*OXPHOS↑, Healthy cells also use mitochondrial oxidative phosphorylation for metabolism while cancer cells use aerobic glycolysis, also known as the Warburg effect
BG↓, statistically significant decrease in glucose among participants compliant with fasting compared with controls
Insulin↓, statistically significant decrease in insulin among participants compliant with fasting compared with regular diet before the first cycle of chemotherapy (p = .001), as well as during the middle of therapy
RadioS↑, A complete or partial radiographic response was also noted more often among fasting participants compared with normal diet participants

4040- VitB12,  FA,    Role of vitamin B12 and folic acid in treatment of Alzheimer’s disease: a meta-analysis of randomized control trials
- Review, AD, NA
*memory↑, After a 6-month treatment, administration of vitamin B12 and folic acid improved the MMSE scores more than placebo did
*neuroP↑, Vitamin B12 and folic acid have been discovered to possess neuroprotective properties, as well as being vital for the growth and functioning of the nervous system
*cognitive↑, four reported changes in MMSE scores, and three reported changes in ADAS-Cog scores.
*QoL∅, The change in daily life function score in the treatment group was not significantly different from that of the control group after the 6-month treatment, regardless of whether it was measured


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

Insulin↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↑, 1,   TumCG↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↑, 1,   Dose∅, 3,   eff↑, 2,   eff↝, 1,   RadioS↑, 1,  

Clinical Biomarkers ⓘ

BG↓, 1,  

Functional Outcomes ⓘ

ChemoSideEff↓, 1,   OS↑, 1,   QoL∅, 2,   toxicity↓, 1,   toxicity↝, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

OXPHOS↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,   QoL∅, 1,   toxicity∅, 1,  
Total Targets: 6

Scientific Paper Hit Count for: QoL, Quality of Life
1 Dichloroacetate
1 diet FMD Fasting Mimicking Diet
1 Vitamin B12
1 Folic Acid, Vit B9
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1141  State#:%  Dir#:6
  wNotes=on  sortOrder:rid,rpid

 

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