QoL Cancer Research Results
QoL, Quality of Life: Click to Expand ⟱
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Quality of Life
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Scientific Papers found: Click to Expand⟱
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Case Report, |
Melanoma, |
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OS↑, DCA therapy, with no concurrent conventional therapy, resulted in regression and stabilization of recurrent metastatic melanoma for over 4 years’ duration, with trivial side effects.
toxicity↓, DCA was noted to have an absence of renal, pulmonary, bone marrow and cardiac toxicity
Dose∅, Active hexose correlated compound or AHCC , dandelion root, curcumin, and astragalus root. Parenteral therapy was also started, which consisted of intravenous vitamin C twice weekly and subcutaneous European mistletoe extract. +vegan diet
Dose∅, DCA 500 mg 3 times per day, which was equivalent to 17 mg/kg per day (manufacturer: Tokyo Chemical Industry, United States) in addition to maintaining the other natural therapies. 2 wk on and 1 wk off
Dose∅, To minimize the occurrence of DCA side effects, 3 additional natural medications were prescribed: Oral acetyl L-carnitine 500 mg 3 times a day, oral benfotiamine 80 mg twice a day and oral R-alpha lipoic acid 150 mg 3 times a day
QoL∅, DCA therapy can be used without reducing quality of life
QoL∅, DHA supplementation did not significantly affect QoL, aerobic exercise volume or resistance training frequency during treatment.
*toxicity∅, Data suggest overall good compliance, no malnutrition, minimal side effects. No significant changes were identified to suggest increased harm.
QoL∅, unchanged quality of life (QOL),
eff↑, improved endocrine parameters
eff↝, mixed results for cancer outcomes
ChemoSideEff↓, decreasing chemotherapy-related side effects
TumCG↓, limiting tumor growth
Dose↑, When fasting is used as an adjunct to chemotherapy, a minimum fasting period of at least 48 hours is currently recommended for nutritional interventions in order to achieve a measurable metabolic response at the cellular level
toxicity↝, The increased risk for poor outcomes associated with malnutrition, weight loss, and cachexia poses an obvious safety concern for patients with cancer who participate in calorie-restricted fasting
eff↑, short-term fasting involving water-only or limited daily calorie consumption for less than a week has the potential to achieve positive metabolic changes while avoiding malnutrition and significant weight loss
IGF-1↑, statistically significant decrease in IGF-1 among participants compliant with fasting compared with regular diet during the middle of therapy
*OXPHOS↑, Healthy cells also use mitochondrial oxidative phosphorylation for metabolism while cancer cells use aerobic glycolysis, also known as the Warburg effect
BG↓, statistically significant decrease in glucose among participants compliant with fasting compared with controls
Insulin↓, statistically significant decrease in insulin among participants compliant with fasting compared with regular diet before the first cycle of chemotherapy (p = .001), as well as during the middle of therapy
RadioS↑, A complete or partial radiographic response was also noted more often among fasting participants compared with normal diet participants
Dose↝, Four hundred twenty-one assessable patients with cancer-associated wasting were randomly assigned to an EPA supplement 1.09 g administered bid plus placebo; MA liquid suspension 600 mg/d plus an isocaloric, isonitrogenous supplement administered twic
Weight↑, A smaller percentage taking the EPA supplement gained >or= 10% of baseline weight compared with those taking MA: 6% v 18%, respectively (P =.004).
eff↑, Combination therapy resulted in weight gain of >or= 10% in 11% of patients (P =.17 across all arms).
OS∅, Survival was not significantly different among arms.
QoL∅, Global quality of life was not significantly different among groups.
QoL∅, There was no significant difference in the median quality of life scores between the 2 cohorts,
QoL↑, however, when evaluating the individual quality of life metrics, 5 out of the 23 metrics showed statistically significant improvement, and none of the quality-of-life metrics declined in the oligo fucoidan group as compared to the placebo group.
DCR↑, results indicate that LMF combined with chemotarget agents significantly improved the DCR.
OS∅, OS, PFS, ORR, AEs, and QOL did not significantly differ between the two groups
PFS∅,
ORR∅,
AEs∅,
QoL∅,
TumCCA↑, Among the anticancer mechanisms of fucoidan are cell cycle arrest, apoptosis evocation, and stimulation of cytotoxic natural killer cells and macrophages.
Apoptosis↑,
NK cell↑,
chemoP↑, Fucoidan also protects against toxicity associated with chemotherapeutic drugs and radiation-induced damage.
TumCG↓, fucoidan slows tumor growth, kills cancer cells, and interacts with cancer chemotherapy drugs.
*Inflam↓, fucoidan has countless superior biological activities, which include anti-inflammatory, antioxidant, anticlotting, antithrombotic, antiviral, anti-angiogenesis, and anti-Helicobacter pylori activities
*antiOx↑,
*AntiThr↑,
*AntiViral↑,
angioG↓,
ChemoSen↑, Furthermore, LMWF complexed with tamoxifen, cisplatin, or paclitaxel shows cell growth inhibition, cellular apoptosis, and arrest of the cell cycle in the human breast cancer cell line MCF-7/ MDA-MB-231.
ROS↑, The study revealed that in breast cancer cells, phosphorylation of different proteins, elevation the reactive oxygen species (ROS) levels, and reduced glutathione (GSH) levels were all crucial in cancer cell apoptosis
GSH↓,
mtDam↓, reatment with fucoidan leads to increased levels of ROS in cells, along with mitochondrial damage and mitochondrial membrane potential (MMP) depolarization.
MMP↓,
DNMT3B↓, inhibition of its downstream target DNA methyltransferase 3B (DNMT3B) by the administration of a fixed dose of fucoidan
TumCG↓, Oral administration of fucoidan (5 mg/kg) effectively inhibited tumor growth in mice grown with B16 melanoma cells.
Dose↝, fucoidan (5 mg/kg) effectively inhibited tumor growth in mice
Dose↝, Twenty patients with advanced cancer were selected for the study, in which oral fucoidan (4 g daily) was administered for at least four weeks. After two consecutive weeks of ingestion, there was a significant reduction in the levels of key proinflamm
QoL∅, but no significant change was observed in patients’ quality of life, including the experience of fatigue
fatigue∅,
Dose↝, 300 mg fucoidan is safe and well tolerated by humans
*memory↑, After a 6-month treatment, administration of vitamin B12 and folic acid improved the MMSE scores more than placebo did
*neuroP↑, Vitamin B12 and folic acid have been discovered to possess neuroprotective properties, as well as being vital for the growth and functioning of the nervous system
*cognitive↑, four reported changes in MMSE scores, and three reported changes in ADAS-Cog scores.
*QoL∅, The change in daily life function score in the treatment group was not significantly different from that of the control group after the 6-month treatment, regardless of whether it was measured
Showing Research Papers: 1 to 8 of 8
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8
Pathway results for Effect on Cancer / Diseased Cells:
NA, unassigned(tgid=0) ⓘ
AEs∅, 1, DCR↑, 1, ORR∅, 1, PFS∅, 1,
Redox & Oxidative Stress(tgid=1) ⓘ
GSH↓, 1, ROS↑, 1,
Mitochondria & Bioenergetics(tgid=3) ⓘ
Insulin↓, 1, MMP↓, 1, mtDam↓, 1,
Cell Death(tgid=5) ⓘ
Apoptosis↑, 1,
DNA Damage & Repair(tgid=10) ⓘ
DNMT3B↓, 1,
Cell Cycle & Senescence(tgid=11) ⓘ
TumCCA↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
IGF-1↑, 1, TumCG↓, 3,
Angiogenesis & Vasculature(tgid=14) ⓘ
angioG↓, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
NK cell↑, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
ChemoSen↑, 1, Dose↑, 1, Dose↝, 4, Dose∅, 3, eff↑, 3, eff↝, 1, RadioS↑, 1,
Clinical Biomarkers(tgid=22) ⓘ
BG↓, 1,
Functional Outcomes(tgid=23) ⓘ
chemoP↑, 1, ChemoSideEff↓, 1, fatigue∅, 1, OS↑, 1, OS∅, 2, QoL↑, 1, QoL∅, 7, toxicity↓, 1, toxicity↝, 1, Weight↑, 1,
Total Targets: 34
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↑, 1, OXPHOS↑, 1,
Transcription & Epigenetics(tgid=7) ⓘ
AntiThr↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
Inflam↓, 1,
Functional Outcomes(tgid=23) ⓘ
cognitive↑, 1, memory↑, 1, neuroP↑, 1, QoL∅, 1, toxicity∅, 1,
Infection & Microbiome(tgid=24) ⓘ
AntiViral↑, 1,
Total Targets: 10
Scientific Paper Hit Count for: QoL, Quality of Life
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:1141 State#:% Dir#:6
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