hepatoP Cancer Research Results

hepatoP, L,hepatoprotective: Click to Expand ⟱
Source:
Type:
Hepatoprotective is the ability of a chemical substance to prevent damage to the liver.

Grapefruit:
-hepatoprotective potential has emerged from the study of naringenin and naringin.
Blueberries/cranberries:
-proanthocyanidins
Grape:
Nopal (Cactus pear) and tuna (Cactus pear fruit) “Opuntia ficus-indica”:
Chamomile (Matricaria chamomilla or Chamomilla recutita):
Silymarin (Silybum marianum):
Blue green algae spirulina :
Propolis (bee glue):

POLYSACCHARIDES
β-glucans
Scientific Papers found: Click to Expand⟱
5428- AG,    Meta-Analysis of Astragalus-Containing Traditional Chinese Medicine Combined With Chemotherapy for Colorectal Cancer: Efficacy and Safety to Tumor Response
- Review, CRC, NA
ChemoSen↑, This meta-analysis indicated that the combination of Astragalus-based Chinese medicines and chemotherapy may increase the efficiency of tumor response rate (TRR) for the treatment of CRC patients
chemoP↑, Astragalus-based product with chemotherapy group was found to have lower nausea and vomiting. Astragalus-based product with chemotherapy treatment suffered with a lower diarrhea
QoL↑, The results of this meta-analysis of 1,409 patients showed that Astragalus-based product combined with chemotherapy in the treatment of CRC may increase the efficiency of TRR, improve their life quality, and reduce some side effects
RenoP∅, Hepatic dysfunction (RR: 0.76; 95% CI: 0.53–1.09; p = 0.13) and renal dysfunction (RR: 0.95; 95% CI: 0.51–1.76; p = 0.87) were similar between two groups.
hepatoP∅, Astragalus-based product with chemotherapy had no improvement in the hepatic and renal dysfunction when compared with treatment of chemotherapy alone.

7335- Gra,    Effect of Annona muricata (Soursop) on Patients with Cancer: A Systematic Review
- Review, Var, NA
TumCG↓, Annona muricata has shown to inhibit cancer cell growth, enhance caspase activity, and provide anti-inflammatory effects.
Casp↑,
Inflam↓,
toxicity↓, It was found to be safe, with minimal side effects in cancer patients. Annona muricata does not interfere with bone marrow, liver, and kidney function and may even improve nutritional status
other↑, Annona muricata is among the most commonly used herbal remedies by cancer patients.
TumCCA↑, by inducing tumour cell death via various mechanisms such as controlling the cell cycles (causing cell arrest in the G1 phase), and promoting apoptosis by inhibiting multiple proteins while also inducing autophagy
Apoptosis↑,
TumAuto↑,
ATP↓, acetogenins can inhibit mitochondrial ATP formation and suppress cancer cell growth by facilitating the nuclear translocation of apoptosis-inducing factor (AIF) and promoting AIF-dependent cell death
AIF↑,
MMP↓, cascade of caspases. Annomuricin E causes a reduction in mitochondrial membrane potential (MMP), which results in the opening of mitochondrial permeability transition pores and the subsequently release of pro-apoptotic proteins like cytochrome C.
MOMP↑,
Cyt‑c↑,
selectivity↑, One mouse study reported that Annona muricata significantly inhibited the growth of MDA-MB-468 cell lines, with an IC50 of 4.8 μg/ml, while showing no effect on MCF-10 cell lines
hepatoP∅, owing that Annona muricata did not induce hepatotoxicity and nephrotoxicity.


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Casp↑, 1,   Cyt‑c↑, 1,   MOMP↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   hepatoP∅, 2,   QoL↑, 1,   RenoP∅, 1,   toxicity↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: hepatoP, L,hepatoprotective
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1179  State#:%  Dir#:6
  wNotes=on  sortOrder:rid,rpid

 

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