APP Cancer Research Results

APP, amyloid precursor protein: Click to Expand ⟱
Source:
Type:
APP typically refers to the amyloid precursor protein, best known for its role in Alzheimer’s disease.
-APP is mainly distributed in the synapses of neurons in the brain and Aβ peptide was produced from APP proteolysis by β-secretase and γ-secretase complex.
-decreased APP in 5×FAD mice ameliorated their amyloid plaques and behavior activity.

• APP is found to be upregulated in some cancers such as certain breast cancers, colon cancers, and lung cancers. Elevated levels may influence processes such as cell proliferation, adhesion, migration, and even invasion.
Scientific Papers found: Click to Expand⟱
3735- MF,    Examining the effects of extremely low-frequency magnetic fields on cognitive functions and functional brain markers in aged mice
- in-vivo, AD, NA
*APP∅, *Aβ∅, *Inflam∅, *memory∅,
3743- RF,    Repeated electromagnetic field stimulation lowers amyloid-β peptide levels in primary human mixed brain tissue cultures
- in-vitro, AD, NA
*Aβ↓, *toxicity∅, *APP∅,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Migration ⓘ

APP∅, 2,  

Immune & Inflammatory Signaling ⓘ

Inflam∅, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   Aβ∅, 1,  

Functional Outcomes ⓘ

memory∅, 1,   toxicity∅, 1,  
Total Targets: 6

Scientific Paper Hit Count for: APP, amyloid precursor protein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1300  State#:%  Dir#:6
  wNotes=0  sortOrder:rid,rpid

 

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