AChE Cancer Research Results

AChE, acetylcholinesterase: Click to Expand ⟱
Source:
Type:
AChE is an enzyme that rapidly hydrolyzes the neurotransmitter acetylcholine into choline and acetate, terminating cholinergic signals.
- In some cancers, studies have reported reduced AChE activity, which may contribute to an accumulation of acetylcholine.
- Lower levels or loss of AChE expression/activity have been associated with more aggressive tumor behavior and poor prognosis, possibly due to unchecked cholinergic signaling.

For AD (Alzheimer's), AChE inhibitors are used, to allow ACh, and ChAT to increase along with acetyl-CoA
-Natural AChE inhibitors: Ferulic Acid, Caffeic Acid, Rosmarinic Acid, Sage
-AChE inhibitors only temporarily relieve some of the disease’s cognitive symptoms and do not stop the patient’s cognitive loss
-adverse effects such as disorientation, falls, dizziness, and fatigue may occur with these medications and should be used only as recommended

- Natural AChE inhibitors paper
Scientific Papers found: Click to Expand⟱
3824- Aroma,    Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties
- Human, AD, NA
*cognitive↑, The most notable cognitive and mood effects were improved memory performance and increased 'calmness' at all postdose time points for the highest (1600 mg) dose.
*memory↑,
*AChE∅, However, no cholinesterase inhibitory properties were detected
*Mood↑,
*eff↝, The results also suggest that different preparations derived from the same plant species may exhibit different properties depending on the process used for the sample preparation.

6655- Cen,    Centella asiatica improves cognitive function and alters the hippocampal metabolome of aged Tg2576 and wild-type mice
- in-vivo, AD, NA
*cognitive↑, Mechanisms underlying CAW's cognitive effects extend beyond reversing metabolic effects of Aβ accumulation.
*Dose↝, oral administration of a CA water extract (CAW) at 200 mg per kg of body weight per day (mg/kg/d) for 5 weeks improved cognitive deficits in both the Tg2576 23 and 5XFAD24,25 transgenic mouse models of AD.
*memory↑, improved learning and memory of Tg2576 mice in the Morris water maze paradigm without altering Aβ levels in the cortex in vivo or inhibiting acetylcholinesterase enzyme in vitro.
*AChE∅,
*mtDam↓, CAW in vitro improves antioxidant response, ameliorates mitochondrial dysfunction, and increases dendritic arborization.
*antiOx↑,

6649- Cen,    Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action
- in-vivo, AD, NA
*eff↑, Orally administered GKW attenuated β-amyloid-associated behavioral abnormalities in these mice.
*memory↑, CA extract markedly improved learning and memory of wild-type rats
*NO↓, GKW inhibited NO production induced by Aβ but did not influence LPS-induced NO levels in these cells.
*cognitive↑, Other potential mechanisms by which GKW may have improved cognitive function in the Tg2576 mice were also investigated
*AChE∅, No direct inhibitory effect of GKW (2.5 to 250 μg/mL) on cholinesterase activity in vitro was observed

7406- Chy,    Antiamnesic activity of an ayurvedic formulation chyawanprash in mice
- in-vivo, AD, NA
*Dose↝, beneficial effects of Chy (at the dose of 1 and 2% w/w of diet) administered daily for 15 successive days in mice with memory deficits.
*memory↑, The administration of Chy for 15 consecutive days significantly protected the animals from developing memory impairment.
*TBARS↓, there was a significant decrease in brain TBARS and increase in GSH levels after administration of Chy (2% w/w), thereby indicating decreased free radical generation and increased scavenging of free radical, respectively
*GSH↑,
*ROS↓,
*cognitive↑, Thus, Chy may prove to be a useful remedy for the management of Alzheimer's disease owing to its antioxidant effect, pro-cholinergic action and/or antiamnesic potential.
*AntiAge↑, Chy had been one of the most respected anti-ageing ayurvedic tonic, long before the clinical importance of vitamins, minerals and antioxidants was appreciated
*hepatoP↑, It is not only hepatoprotective but it also streamlines the metabolism of fats and proteins
*antiOx↑, It possesses promising antioxidant, cardiotonic, cholesterol lowering and anti-inflammatory properties
*LDL↓,
*Inflam↓,
*other↝, Chy is made in anwala base (Indian gooseberry, Emblica officinalis) [16], which is one of the richest sources of vitamin C (ascorbic acid)
*AChE∅, No statistically significant differences were observed in brain AChE activity of Chy-treated mice and control group mice.

3779- FA,    A review on ferulic acid and analogs based scaffolds for the management of Alzheimer’s disease
- Review, AD, NA
*antiOx↑, antioxidant, neuroprotection, Aβ aggregation modulation, and anti-inflammatory.
*neuroP↑,
*Aβ↓,
*Inflam↓,
*COX2/PTGS2↓, , FA inhibits various cytotoxic enzymes’ upregulation, including cyclooxygenase (COX), caspases, and nitric oxide synthase.
*Casp↓,
*NOS2↓,
*HO-1↑, It also upregulates different cytoprotective enzymes such as threonine kinase and heme oxygenase-1 [79].
*AChE∅, recent research work from our laboratory have strongly implicated that FA does not effectively interact with AChE and BChE (<20% inhibition of AChE and BChE at 20 mM)
*BChE∅,
*memory↑, FA to the transgenic mouse model of AD could enhance learning and memory and reduce the toxic Aβ fibrils level


Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   GSH↑, 1,   HO-1↑, 1,   ROS↓, 1,   TBARS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Casp↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Inflam↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE∅, 5,   BChE∅, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 2,   eff↑, 1,   eff↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   cognitive↑, 4,   hepatoP↑, 1,   memory↑, 5,   Mood↑, 1,   neuroP↑, 1,  
Total Targets: 25

Scientific Paper Hit Count for: AChE, acetylcholinesterase
2 Centella asiatica / Gotu kola → asiaticoside
1 Aromatherapy
1 Chyawanprash
1 Ferulic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1329  State#:%  Dir#:6
  wNotes=on  sortOrder:rid,rpid

 

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