Aβ Cancer Research Results
Aβ, Aβ aggregation: Click to Expand ⟱
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Beta-Amyloid (Aβ): In Alzheimer’s disease, Aβ peptides tend to misfold and aggregate into oligomers and fibrils.
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Scientific Papers found: Click to Expand⟱
*APP∅, No difference in hippocampal expression of APP-695, Aβ(1−42), S100b and GFAP proteins or in the pTau/Tau ratio was observed between sham- and ELF-MF-exposed aged mice
*Aβ∅,
*Inflam∅, ELF-MFs does not aggravate aging and associated neuroinflammation, or promote pathological pathways involved in the initiation of AD
*memory∅, However, sham- and ELF-MF-exposed aged mice were equally able to discriminate the newly accessible arm during the test phase, which resulted in a spatial recognition memory performance above chance level
*Weight∅, body weight of rats showed no difference compared with the control group.
*memory∅, application of ELF-EMF did not induce any cognitive and memory impairment compared with the sham-exposure group.
*cognitive∅,
*Aβ∅, Aβ showed no significant change between the two groups,
*antiOx↑, potentially known to have antioxidant and anti-inflammatory properties
*Inflam↓,
*memory↑, R. officinalis improved cognitive abilities, it did not reduce the amyloid plaque burden
*Aβ∅,
*GutMicro↑, rebalanced gut microbiota
*cognitive↑, Our previous study indicates that oral supplementation of taurine at 1000 mg/kg/day significantly ameliorates hippocampal-dependent cognitive deficits in APP/PS1 transgenic AD mouse model
*Aβ∅, Aβ plaques and oligomeric Aβ levels are not affected after administration of taurine
*other↑, Our results propose that taurine can ameliorate cognitive impairment by directly binding to oligomeric Aβ in oral administration of 250 mg/kg/day for 10 days.
*neuroP↑, brain uptake in the taurine-treated AD group was 31–40% higher than that in the AD group . Therefore, taurine has therapeutic potential against AD.
*Aβ∅, taurine supplementation did not reduce amyloid pathology in the AD animal model
*cognitive↑, intravenously administered taurine prevents Aβ neurotoxicity and cognitive impairment
*toxicity↓, Our study also revealed no severe side effects in rodents despite the long-term use of taurine for 7 months.
*Ca+2↓, taurine reduced abnormal Ca2+ signaling in sensory neurons, which reduced glutamate-mediated toxicity
*memory↑, Jang et al.18 reported that taurine did not affect Aβ plaque levels in the APP/PS1 model but interacted directly with AβO, which led to enhanced memory function
Showing Research Papers: 1 to 5 of 5
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5
Pathway results for Effect on Cancer / Diseased Cells:
Total Targets: 0
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 1,
Transcription & Epigenetics ⓘ
other↑, 1,
Migration ⓘ
APP∅, 1, Ca+2↓, 1,
Immune & Inflammatory Signaling ⓘ
Inflam↓, 1, Inflam∅, 1,
Protein Aggregation ⓘ
Aβ∅, 5,
Clinical Biomarkers ⓘ
GutMicro↑, 1,
Functional Outcomes ⓘ
cognitive↑, 2, cognitive∅, 1, memory↑, 2, memory∅, 2, neuroP↑, 1, toxicity↓, 1, Weight∅, 1,
Total Targets: 15
Scientific Paper Hit Count for: Aβ, Aβ aggregation
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:1333 State#:% Dir#:6
wNotes=on sortOrder:rid,rpid
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