BDNF Cancer Research Results

BDNF, brain-derived neurotrophic factor: Click to Expand ⟱
Source:
Type:
Brain-Derived Neurotrophic Factor (BDNF) is a key neurotrophin (a type of growth factor) involved in brain health, and its role in Alzheimer’s Disease (AD) has been extensively studied.
-AD patients often have lower BDNF levels in key brain regions, such as the hippocampus and cortex.
-This reduction correlates with cognitive decline and brain atrophy.
-BDNF normally protects neurons from Aβ toxicity
-Exercise and cognitive training have been shown to boost BDNF levels and may slow cognitive decline.
- natural compounds (like curcumin or flavonoids) may also upregulate BDNF.
Scientific Papers found: Click to Expand⟱
4244- Gb,    Effects of Six-Week Ginkgo biloba Supplementation on Aerobic Performance, Blood Pro/Antioxidant Balance, and Serum Brain-Derived Neurotrophic Factor in Physically Active Men
- Human, Nor, NA
*BDNF∅, Our results have evidenced that a six-week consumption of Ginkgo biloba extract did not result in an increase in basal BDNF content.

4173- TQ,    Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons
- in-vivo, NA, NA
*neuroP↑, TQ significantly increases the number of hippocampal neurons.
*Casp3↓, TQ significantly decreases the amount of Caspase-3 expression and the cleavage of poly ADP ribose polymerase, indicating a decrease in apoptosis.
*Apoptosis↓,
*ERK↑, ERK, GSK-3, JNK, CREB, and iNOS proteins are found to be positively regulated by TQ.
*JNK↑,
*CREB↑,
*iNOS↑,
*BDNF∅, gene expression of synapsin, synaptophysin, NGF, AKT, Bax, NFkB, and p53 and the protein expression of BDNF and nNOS are not affected by TQ.

4185- VitD3,    Effects of vitamin D supplementation on neuroplasticity in older adults: a double-blinded, placebo-controlled randomised trial
- Study, NA, NA
*other↑, After 10 weeks, mean 25(OH)D levels increased from 46 to 81 nmol/L in the vitamin D group with no change in the placebo group.
*BDNF∅, There was no effect of vitamin D on muscle power, function or BDNF.

4186- VitD3,    The Association of Vitamin D, Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), and Glial Cell-Derived Neurotrophic Factor (GDNF) with Development in Children
- Study, NA, NA
*BDNF∅, There was no association of vitamin D with NGF, GDNF, or BDNF levels.

4196- Z,    The effect of zinc supplementation on brain derived neurotrophic factor: A meta-analysis
- Review, NA, NA
*BDNF∅, Zinc supplementation may not significantly increase BDNF levels. However, the small number of included articles and significant heterogeneity between them can increase the risk of a false negative result;


Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

CREB↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Casp3↓, 1,   iNOS↑, 1,   JNK↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,  

Synaptic & Neurotransmission ⓘ

BDNF∅, 5,  

Functional Outcomes ⓘ

neuroP↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: BDNF, brain-derived neurotrophic factor
2 Vitamin D3
1 Ginkgo biloba
1 Thymoquinone
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1356  State#:%  Dir#:6
  wNotes=on  sortOrder:rid,rpid

 

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