Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱
Source:
Type: type of cell death
Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.
Scientific Papers found: Click to Expand⟱
1404- BBR,    Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation
- in-vitro, Pca, PC3
Apoptosis↑,
*Apoptosis∅, not seen in non-neoplastic human prostate epithelial cells (PWR-1E)
MMP↓,
cl‑Casp3↑,
cl‑Casp9↑,
cl‑PARP↑,
ROS↑,
eff↓, Treatment of cells with allopurinol, an inhibitor of xanthine oxidase, inhibited berberine-induced oxidative stress in cancer cells.
Cyt‑c↑, release of cytochrome c

4763- CoQ10,  Chemo,  doxoR,    Effect of Coenzyme Q10 on Doxorubicin Cytotoxicity in Breast Cancer Cell Cultures
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
ChemoSen∅, CoQ10 had no effect on the ability of doxorubicin to induce apoptosis or inhibit growth or colony formation in both cell lines tested when CoQ10 was applied over a wide dose range.
antiNeop∅, These results support the hypothesis that CoQ10 does not alter the antineoplastic properties of doxorubicin.
*cardioP↑, hypothesized that dietary supplementation of CoQ10 prior to and during doxorubicin treatment can prevent doxorubicin-induced cardiotoxicity by preventing or slowing the displacement of CoQ10 by doxorubicin metabolites.
Dose↝, A daily dose of 300 mg per day for 11 days has been shown to raise plasma CoQ10 concentrations by 300-400%
selectivity↑, CoQ10 increased the cytotoxic activity of doxorubicin in L-1210 leukemia cells and had no effect in Ehrlich ascites carcinoma cells.3
TumCG∅, CoQ10 does not antagonize the in vitro growth inhibition effect of doxorubicin
TumCG∅, The growth inhibition of doxorubicin alone for BT549 cell line of 53.1% was also not significantly altered by CoQ10 additions
Apoptosis∅, CoQ10 does not diminish apoptotic effect of doxorubicin

4995- Sal,    Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway
- vitro+vivo, BC, MDA-MB-231
ALDH↓, Salinomycin reduces ALDH1 activity and downregulates Nanog, Oct4 and Sox2.
Nanog↓,
OCT4↓,
SOX2↓,
CSCs↓, Salinomycin targets BCSCs via an apoptosis-independent pathway.
tumCV↓, Salinomycin suppressed cell viability, concomitant with the downregulation of cyclin D1 and increased p27kip1 nuclear accumulation.
cycD1/CCND1↓,
P21↑,
TumCG↓, MDA-MB-231-derived xenografts revealed that salinomycin administration elicited a significant reduction in tumor growth with a marked downregulation of ALDH1 and CD44 levels, but seemingly without the induction of apoptosis.
CD44↓,
Apoptosis∅,

3139- VitC,    Vitamin C and sodium bicarbonate enhance the antioxidant ability of H9C2 cells and induce HSPs to relieve heat stress
- in-vitro, Nor, H9c2
*Apoptosis∅, Supplementation with vitamin C and vitamin C-Na for 16 h had no significant influence on apoptosis, LDH or MDA, but SOD activity was significantly reduced about 8.6% for VC
*LDH∅,
*MDA∅,
*SOD↓, SOD activity was significantly reduced about 8.6% for VC. further heat stress at 5 h, SOD activity recovered slightly but was still lower than that at 1 h.
eff↝, Thus, under heat stress conditions, the concentration of vitamin C entering the cell could be much higher than in normal conditions.


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Apoptosis∅, 2,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CD44↓, 1,   CSCs↓, 1,   Nanog↓, 1,   OCT4↓, 1,   SOX2↓, 1,   TumCG↓, 1,   TumCG∅, 2,  

Drug Metabolism & Resistance ⓘ

ChemoSen∅, 1,   Dose↝, 1,   eff↓, 1,   eff↝, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

antiNeop∅, 1,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

MDA∅, 1,   SOD↓, 1,  

Core Metabolism/Glycolysis ⓘ

LDH∅, 1,  

Cell Death ⓘ

Apoptosis∅, 2,  

Clinical Biomarkers ⓘ

LDH∅, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: Apoptosis, Apoptosis
1 Berberine
1 Coenzyme Q10
1 Chemotherapy
1 doxorubicin
1 salinomycin
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:14  State#:%  Dir#:6
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