antiNeop Cancer Research Results

antiNeop, antineoplastic: Click to Expand ⟱
Source:
Type:
Antineoplastic is a medical term that literally means “against new growth” and is used to describe agents or therapies that prevent, inhibit, or kill cancer cells.
-In oncology, antineoplastic usually implies anticancer activity
Scientific Papers found: Click to Expand⟱
4763- CoQ10,  Chemo,  doxoR,    Effect of Coenzyme Q10 on Doxorubicin Cytotoxicity in Breast Cancer Cell Cultures
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
ChemoSen∅, CoQ10 had no effect on the ability of doxorubicin to induce apoptosis or inhibit growth or colony formation in both cell lines tested when CoQ10 was applied over a wide dose range.
antiNeop∅, These results support the hypothesis that CoQ10 does not alter the antineoplastic properties of doxorubicin.
*cardioP↑, hypothesized that dietary supplementation of CoQ10 prior to and during doxorubicin treatment can prevent doxorubicin-induced cardiotoxicity by preventing or slowing the displacement of CoQ10 by doxorubicin metabolites.
Dose↝, A daily dose of 300 mg per day for 11 days has been shown to raise plasma CoQ10 concentrations by 300-400%
selectivity↑, CoQ10 increased the cytotoxic activity of doxorubicin in L-1210 leukemia cells and had no effect in Ehrlich ascites carcinoma cells.3
TumCG∅, CoQ10 does not antagonize the in vitro growth inhibition effect of doxorubicin
TumCG∅, The growth inhibition of doxorubicin alone for BT549 cell line of 53.1% was also not significantly altered by CoQ10 additions
Apoptosis∅, CoQ10 does not diminish apoptotic effect of doxorubicin


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis∅, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG∅, 2,  

Drug Metabolism & Resistance ⓘ

ChemoSen∅, 1,   Dose↝, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

antiNeop∅, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

cardioP↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: antiNeop, antineoplastic
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1403  State#:%  Dir#:6
  wNotes=on  sortOrder:rid,rpid

 

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