Temp Cancer Research Results

Temp, Temperature: Click to Expand ⟱
Source:
Type:
Temperature
Scientific Papers found: Click to Expand⟱
5494- EP,    An Overview of Subnanosecond Pulsed Electric Field Biological Effects: Toward Contactless Technologies for Cancer Treatment
- Review, Var, NA
other↝, Figure 1, equivalent electrical circuit
ROS↑, Another aspect to consider is the fact that PEF application has been shown to result in reactive oxygen species (ROS) production not only in cells71,72 but also in the medium surrounding the cells
Temp∅, Provided the number of pulses and the PRF are not too high, allowing for interpulse heat dissipation, in most cases, thermal effects can even be neglected.
CellMemb↑, he main primary effect of nsPEFs is the permeabilization of both the cell membrane82 and organelle membranes, followed by calcium entry,83 loss of resting membrane potential,62,84 increased cellular K+ efflux,84 activation of VGCC ion channels
Ca+2↑, In addition to apoptosis, nsPEFs are known to trigger calcium mobilization.
Apoptosis↑, The apoptosis is characterized by several morphological changes in the cell, due to energy-dependent biochemical mechanisms, leading to cell death
TumCD↑,
MMP↓, , while the dissipation of ψ (mitochondria membrane potential) occurs at a higher level (around 40 kV/cm)
necrosis↑, A severe dysregulation of Ca2+ stimulates a cell death by necrosis, while a milder dysregulation provokes a cell death by apoptosis.103
TumVol↓, As a result, tumor shrinkage of 90% could be observed within 2 weeks, and the repetition of a second treatment at that time could result in complete regressions.
Remission↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   necrosis↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Migration ⓘ

Ca+2↑, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Cellular Microenvironment ⓘ

Temp∅, 1,  

Functional Outcomes ⓘ

Remission↑, 1,   TumVol↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Temp, Temperature
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1449  State#:%  Dir#:6
  wNotes=on  sortOrder:rid,rpid

 

Home Page