OS Cancer Research Results

OS, overall survival: Click to Expand ⟱
Source:
Type:
Overall survival

Scientific Papers found: Click to Expand⟱
5416- ASA,    Cancer Incidence and Mortality With Aspirin in Older Adults
- Trial, Var, NA
Risk∅, In this study, over a median of 8.6 years, LDA was not associated with incident cancer among older adults, but cancer mortality risk was significantly elevated.
OS∅, However, the elevated cancer mortality risk seen with aspirin for participants in the RCT period did not persist into the post-RCT observation period, suggesting no legacy effect.

5406- ASA,    Adjuvant aspirin therapy and colorectal cancer survival
- Trial, CRC, NA
Dose↝, 1550 participants with resected non-metastatic colorectal cancer from 11 countries or territories in Asia-Pacific and the Middle East were randomly assigned to receive daily aspirin 200 mg or placebo for 3 years.
OS∅, No significant differences were observed in 5-year disease-free survival or overall survival between the aspirin and placebo groups, with hazard ratios (HRs) of 0·91 (95% CI 0·73–1·13) for disease-free survival and 0·75 (0·53–1·07) for os

5596- BEV,    Bevacizumab may improve quality of life, but not overall survival in glioblastoma: an epidemiological study
- Study, GBM, NA
QoL↑, Bevacizumab may improve quality of life, but not overall survival in glioblastoma: an epidemiological study
OS∅,

5717- BF,  Chemo,  GEM,    Prospective randomised evaluation of traditional Chinese medicine combined with chemotherapy: a randomised phase II study of wild toad extract plus gemcitabine in patients with advanced pancreatic adenocarcinomas
- Trial, Var, NA
OS∅, Huachansu when combined with gemcitabine did not improve the outcome of patients with locally advanced and/or metastatic pancreatic cancer.

5812- CBD,    Cannabidiol oil or placebo in advanced cancer-disease progression and survival: a secondary analysis
- Trial, Var, NA
other∅, No significant difference in disease progression was noted between the two groups at days 14 (p=0.33), 28 (p=0.67) or 56 (p=0.50).
OS∅, There was no difference in survival between both groups from study entry to censor date (p=0.38).
other∅, In this substudy analysis, treatment with CBD oil did not affect disease progression or survival over the course of 56 days in patients with advanced cancer.

2163- dietP,  SFN,    Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
- Human, Bladder, NA
OS↑, a strong and significant inverse association was observed between bladder cancer mortality and broccoli intake
OS∅, There were no significant associations for total vegetables, total fruits, or other individual cruciferous vegetables.

4917- DSF,  Chemo,  Cu,    Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients With Recurrent Glioblastoma
- Trial, GBM, NA
OS∅, clinical trial of 88 patients with recurrent glioblastoma, the addition of disulfiram and copper to alkylating chemotherapy did not significantly improve survival at 6 months,
toxicity↑, Six patients (15%) in the experimental group developed elevated liver enzymes compared with no patient in the SOC group

1781- MEL,    Melatonin in patients with cancer receiving chemotherapy: a randomized, double-blind, placebo-controlled trial
- Trial, Lung, NA
QoL↑, Patients in the melatonin-treated group had better adjusted HRQoL scores, with a slightly significantly better score (2.69 points, 95% confidence interval (CI)=0.01-5.38, p=0.049) being found in social well-being
OS∅, Median survival was 7.3 months (95% CI=3.42-11.14) without significant difference (lower survival in placebo group)
selectivity↑, A great amont of DNA damage marker was observed in the placebo-treated group, and this was associated with lower survival (r(2)=-0.656, p=0.02), implying the protective effect of melatonin in healthy cells.


Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics

other∅, 2,  

Drug Metabolism & Resistance

Dose↝, 1,   selectivity↑, 1,  

Functional Outcomes

OS↑, 1,   OS∅, 8,   QoL↑, 2,   Risk∅, 1,   toxicity↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: OS, overall survival
2 Aspirin -acetylsalicylic acid
2 Chemotherapy
1 Bevacizumab (brand Avastin)
1 Bufalin/Huachansu
1 Gemcitabine (Gemzar)
1 Cannabidiol
1 diet Plant based
1 Sulforaphane (mainly Broccoli)
1 Disulfiram
1 Copper and Cu NanoParticles
1 Melatonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:229  State#:%  Dir#:6
wNotes=on sortOrder:rid,rpid

 

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