PDH Cancer Research Results

PDH, mitochondrial pyruvate dehydrogenase (PDH): Click to Expand ⟱

Source:

Type:

-An enzyme complex that plays a crucial role in cellular metabolism, particularly in the conversion of pyruvate to acetyl-CoA, which is then used to produce energy in the form of ATP. -Key enzyme in cellular metabolism that catalyzes the conversion of pyruvate (produced during glycolysis) into acetyl-CoA, which then enters the tricarboxylic acid (TCA) cycle in the mitochondria.
The phosphorylation state of PDH (p-PDH) broadly exists in the cancer cells.
Some cancer cells have been found to inhibit PDH activity, which can lead to increased lactate production and a shift towards glycolysis, even in the presence of oxygen. This is known as the Warburg effect.
-In cancer cells, PDH has been shown to be inhibited.
PDH expression is regulated by various transcription factors, including HIF-1α, c-Myc, and p53.

Scientific Papers found: Click to Expand⟱

2417-

SK,

Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer

in-vitro,

Lung,

A549

in-vitro,

Lung,

H446

TumCP↓, TumCMig↓, TumCI↓, GlucoseCon↓, lactateProd↓, PFKFB2↓, Warburg↓, GLUT1∅, LDHA∅, PKM2∅, GLUT3∅, PDH∅,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

GlucoseCon↓, 1, lactateProd↓, 1, LDHA∅, 1, PDH∅, 1, PFKFB2↓, 1, PKM2∅, 1, Warburg↓, 1,

Migration ⓘ

TumCI↓, 1, TumCMig↓, 1, TumCP↓, 1,

Barriers & Transport ⓘ

GLUT1∅, 1, GLUT3∅, 1,
Total Targets: 12

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: PDH, mitochondrial pyruvate dehydrogenase (PDH)

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells