PSA Cancer Research Results

PSA, prostate-specific antigen: Click to Expand ⟱
Source:
Type:
Prostate-Specific Antigen (PSA) is a protein produced by both normal and malignant cells of the prostate gland. PSA testing is commonly used as a screening tool for prostate cancer.
Elevated levels of PSA in the blood can indicate the presence of prostate cancer, but they can also be caused by other conditions, such as benign prostatic hyperplasia (BPH) or prostatitis (inflammation of the prostate).

PSA is a clinical biomarker.
Scientific Papers found: Click to Expand⟱
6584- EU,    Eurycoma longifolia: an overview on the pharmacological properties for the treatment of common cancer
- Review, Var, NA
*AntiAge↑, he aqueous extract and decoction made from its root have been shown to enhance fertility, sexual activity and possess anti-aging properties.
*Inflam↓, he anti-malarial, anti-inflammatory, anti-oxidant and anti-microbial are the most common activities exerted by this plant.
*antiOx↑,
TumCD↑, Initially, eurycomanone is reported to induce cell death via down regulating of Bcl-2 protein together with cleavage of protein caspase-7 and PARP-1.
Bcl-2↓,
cl‑Casp7↑,
cl‑PARP↑,
BAX↑, increase of the proteins bax and p53, as well as the inhibition of the protein Bcl-2, in a number of cancer cells.
P53↑,
tumCV↓, Treatment on malignant cells with eurycomanone including (HeLa, CaOv, HepG2, MCF7, HM3KO) cell lines greatly decreases quantity of viable cells.
selectivity↑, It is also found that the eurycomanone is relatively benign to non-cancer cell lines (i.e. Vero, MDBK)
*testos↑, It also mentioned E. longifolia extract raises serum testosterone levels, there may be a danger risk associated with its use in older men because it could result in prostatic issues.
*PSA∅, no change in serum levels of prostate-specific antigen (PSA) between the verum and placebo groups.

1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, reduced prostate cancer-specific mortality in men at high risk for prostate cancer
ChemoSen↑, improved the response to docetaxel chemotherapy in advanced castrate-resistant prostate cancer
QoL↑, lycopene improved the quality of life, and provided relief from bone pain and control of lower urinary tract symptoms
PSA∅, PSA stabilisation in prostate cancer
eff↑, Lycopene co-supplementation with vitamin E also showed an improvement in the results of prostate cancer treatment
AntiCan↑, lycopene intake showed a strong protective effect against stomach cancer, regardless of H. pylori status
AntiCan↑, A lycopene-rich diet was shown to reduce the incidence of pancreatic cancer in humans by 31%
angioG↓,
VEGF↓,
Hif1a↓,
SOD↑,
Catalase↑,
GPx↑,
GSH↑,
GPx↑,
GR↑,
MDA↓,
NRF2↑,
HO-1↑,
COX2↓,
PGE2↓,
NF-kB↓,
IL4↑,
IL10↑,
IL6↓,
TNF-α↓,
PPARγ↑,
TumCCA↑, G(0)/G(1) phase
FOXO3↓,
Casp3↑,
IGF-1↓, breast cancer,crc
p27↑,
STAT3↓,
CDK2↓,
CDK4↓,
P21↑,
PCNA↓,
MMP7↓,
MMP9↓,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GPx↑, 2,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   NRF2↑, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   cl‑Casp7↑, 1,   p27↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXO3↓, 1,   IGF-1↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

MMP7↓, 1,   MMP9↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   IL10↑, 1,   IL4↑, 1,   IL6↓, 1,   NF-kB↓, 1,   PGE2↓, 1,   PSA∅, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,   PSA∅, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   OS↑, 1,   QoL↑, 1,  
Total Targets: 47

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   PSA∅, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

PSA∅, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: PSA, prostate-specific antigen
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:264  State#:%  Dir#:6
  wNotes=on  sortOrder:rid,rpid

 

Home Page